A retrotransposon of the non-long terminal repeat class from the human blood fluke Schistosoma mansoni. Similarities to the chicken-repeat-1-like elements of vertebrates

Molecular Biology and Evolution
A C Drew, Paul J Brindley

Abstract

The genomes of representative species of fishes, amphibians, and reptiles contain non-long-terminal-repeat (non-LTR) retrotransposons showing strong sequence identity to the chicken repeat 1 (CR1) non-LTR retrotransposon from birds. These nonavian retroelements have been termed CR1-like elements. We have isolated sequences of a non-LTR retrotransposon from the human blood fluke Schistosoma mansoni. These schistosome sequences, which we have termed the SR1 family of non-LTR retrotransposons, contain regions of deduced amino acids characteristic of the CR1-like elements. SR1 elements possess atypical 3' termini consisting of the tandem repeat (AACCATTTG)2 which are similar in structure to the imperfect tandem repeat of the 3' termini of CR1. There are at least 200 copies of SR1 interspersed through the genome of S. mansoni. The structural and amino acid sequence similarities of SR1 with members of the CR1-like elements suggest that the SR1 family belongs to the CR1-like category of non-LTR retrotransposons. Although other non-LTR retrotransposons have been described in invertebrates, this is the first CR1-like element reported from a nonvertebrate taxon, suggesting that the phylogenetic distribution of CR1-like retrotransposons i...Continue Reading

Citations

Apr 8, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D A JohnstonS E Melville
Dec 14, 2004·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Nickolche SirijovskiJean M P Joss
Aug 5, 2008·Functional & Integrative Genomics·Olga NovikovaAlexander Blinov
Oct 20, 2005·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Philippe CoullinV Volobouev
Jun 9, 2005·Biochemical and Biophysical Research Communications·Ricardo DeMarcoSergio Verjovski-Almeida
Sep 19, 2003·International Journal for Parasitology·Jon P Boyle, Timothy P Yoshino
Feb 15, 2003·Trends in Parasitology·Paul J BrindleyAlex Loukas
Jan 10, 2003·Molecular Biology and Evolution·Vladimir V Kapitonov, Jerzy Jurka
Apr 12, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kristine J KinesPaul J Brindley
Apr 2, 2010·Population Health Metrics·Mohsen NaghaviMohammad Esmail Motlagh
Jun 26, 2008·The Journal of Parasitology·C L L ValentimE H Babá
Aug 22, 2014·Nucleic Acids Research·Yoshinori HayashiNorihiro Okada
Sep 1, 2009·Gene·Michelle L ThompsonDavid A Ray
Sep 15, 2004·Gene·Stefania FantaccioneGiovanni Pontecorvo
Sep 27, 2005·Molecular Phylogenetics and Evolution·Judith St JohnThomas W Quinn
Dec 19, 2009·International Journal for Parasitology·Thiago M VenancioRicardo DeMarco
Nov 19, 2004·Molecular Biology and Evolution·Masaki KajikawaNorihiro Okada
Aug 12, 2005·Cytogenetic and Genome Research·N ZinglerG G Schumann
Dec 31, 2003·The Korean Journal of Parasitology·Young-An Bae, Yoon Kong
Jun 12, 1998·Tropical Medicine & International Health : TM & IH·A C DrewD J Minchella
Jan 29, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Samuel F Schluter, John J Marchalonis
Jul 22, 2005·Molecular Biology and Evolution·James L CraineyColin A Malcolm
Jun 26, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria E MoralesPaul J Brindley
Jul 22, 2021·Tropical Medicine and Infectious Disease·Gisele Strieder Philippsen

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