A reversible decomposition approach for the formation of injectable, excipient-free, self-assembling nanocrystals

Chemical Communications : Chem Comm
Qin YangTao Gong

Abstract

We have formulated 7-ethyl-10-hydroxy camptothecin (SN38) nanocrystals using a novel combination of reversible reactions and pharmaceutical technology. The nanocrystals are taken up more efficiently by cells and accumulate more in tumors than the commercially available camptothecin compound irinotecan (CPT-11), leading to superior anti-tumor efficacy in vitro and in vivo.

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Citations

Oct 11, 2021·International Journal of Pharmaceutics·Dnyaneshwar KalyaneRakesh Kumar Tekade

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Methods Mentioned

BETA
dynamic light scattering
electron microscopy
X-ray
confocal microscopy

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