A reversible tracer analysis approach to the study of effective dopamine turnover

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
V SossiJ E Holden

Abstract

Changes in dopamine turnover resulting from disease states such as Parkinson's disease may be reflected in corresponding changes in the kinetics of the positron emission tomographic tracer [(18)F]fluorodopa. The authors had previously refined the conventional irreversible-tracer graphical approach to determine both the uptake rate constant K(i) and the rate constant kloss that describes the slow loss of the trapped kinetic component. Because these parameters change in the opposite sense with disease, their ratios may be more powerfully discriminating than either one alone. The ratio k(loss)/K(i) is indicative of effective dopamine turnover. Its inverse, K(i)/k(loss), can be interpreted as the effective distribution volume (EDV) of the specific uptake compartment referred to the fluorodopa concentration in plasma. Here the authors present a new approach to the estimation of EDV based on reversible-tracer graphical methods. When implemented with a plasma input function, the method evaluates EDV directly. When implemented with a tissue input function, the outcome is proportional to the ratio of the distribution volumes of the specific uptake and precursor compartments. Comparison of the new and previous approaches strongly validat...Continue Reading

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Citations

Jan 29, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·A Jon Stoessl
Mar 1, 2011·Expert Opinion on Medical Diagnostics·Raúl de la Fuente-FernándezVesna Sossi
Oct 1, 2013·PET Clinics·Shichun PengYilong Ma
Jan 25, 2016·Biological Psychiatry·Lena RademacherIngo Vernaleken
Jun 16, 2009·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller
Aug 30, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew D WalkerVesna Sossi
Jun 11, 2008·Neurobiology of Aging·Yoshitaka KumakuraPaul Cumming
Jun 4, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Catherine L GallagherSterling C Johnson
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·A Jon StoesslDavid Eidelberg
Oct 13, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Vesna SossiJon A Stoessl
May 22, 2016·Biological Psychiatry·Jodi J WeinsteinAnissa Abi-Dargham
Oct 3, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·A Jon Stoessl
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Sep 25, 2012·Frontiers in Neuroendocrinology·Jennifer C Felger, Andrew H Miller
Aug 5, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoshitaka KumakuraPaul Cumming
Aug 22, 2014·Journal of Medicinal Chemistry·Markus PielFrank Rösch
Sep 15, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Vesna SossiJon Stoessl
Feb 2, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Vesna SossiT J Ruth
Nov 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Keisuke MatsubaraHiroshi Ito
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