PMID: 1509119Jun 1, 1992Paper

A review and biological risk assessment of sodium saccharin

Regulatory Toxicology and Pharmacology : RTP
C I Chappel

Abstract

Dietary sodium saccharin is associated with bladder tumors when fed at high levels to the male rat. Under these conditions urinary pH, sodium concentration, and volume are elevated and proliferative changes are present in the urothelium. Extensive epidemiological studies have shown that saccharin does not increase the risk of bladder cancer in humans and laboratory investigations have shown that sodium saccharin is not mutagenic and does not bind to DNA. Recent research indicates that the urothelium in male rats is damaged under conditions of high urinary pH and sodium levels by a mechanism that involves alpha 2u-globulin and possibly silicate crystalluria. These studies and their implications for human health risk are reviewed.

References

Jul 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L Anderson
May 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A P de GrootH R Immel
Oct 1, 1986·Toxicology and Applied Pharmacology·S L JohanssonS M Cohen
Apr 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J Ashby
Apr 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Roberts, A G Renwick
Apr 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G P Schoenig, R L Anderson
Apr 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G P SchoenigF W Carlborg
Feb 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R M RigginG W Kinzer
Feb 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S FukushimaN Ito
Feb 1, 1983·Cancer Letters·A G Renwick, J Sims
Jan 1, 1980·Toxicology and Applied Pharmacology·D L ArnoldI C Munro

❮ Previous
Next ❯

Citations

Nov 23, 2006·Food Additives and Contaminants·Meenakshi TripathiMukul Das
May 10, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shadia M IhlasehJoão Lauro V de Camargo
May 4, 2012·World Journal of Gastroenterology : WJG·Xiaofa Qin
Dec 10, 2013·Journal of Photochemistry and Photobiology. B, Biology·Ceyda Icsel, Veysel T Yilmaz
Aug 1, 1996·Drug and Chemical Toxicology·S F VelazquezV J Cogliano
Oct 19, 2006·Toxicology and Applied Pharmacology·Jaydip DasguptaDouglas G Tincello
Jul 13, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·MeeKyung KimHoonjeong Kwon
Nov 30, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Terry R Van VleetMark A Dominick
Apr 12, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sarah H Tannehill-GreggMark A Dominick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.