A review and expert opinion of the use of certolizumab for Crohn's disease

Expert Opinion on Biological Therapy
Ashley T Evans, Scott D Lee

Abstract

Crohn's disease (CD) is a chronic, idiopathic, inflammatory bowel disease with no known cure. In those patients with moderate to severe disease, the result is often a clinically debilitating condition. In the last decade, one of the most significant developments in therapy has been a class of biological agents that neutralize TNFa. Certolizumab pegol (CZP) is the most recently FDA approved anti-TNF agent for the induction and maintenance of moderate to severely active Crohn's disease. The currently available evidence regarding the use of CZP in CD, the expected efficacy and possible adverse events associated with this population. CZP is a TNFa inhibitor that is a safe and effective agent for treatment of CD. It has several unique features which make it useful in patients with moderate to severe disease.

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Citations

Sep 5, 2015·Mediators of Inflammation·Bruno Rafael Ramos de MattosPatricia Ucelli Simioni
Mar 7, 2017·Immune Network·Duk Hwan Kim, Jae Hee Cheon
Jul 18, 2014·Psychotherapy Research : Journal of the Society for Psychotherapy Research·Martin PinquartDaniela Teubert

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