A review of 10 years of human microbiome research activities at the US National Institutes of Health, Fiscal Years 2007-2016

Microbiome
NIH Human Microbiome Portfolio Analysis Team

Abstract

The National Institutes of Health (NIH) is the primary federal government agency for biomedical research in the USA. NIH provides extensive support for human microbiome research with 21 of 27 NIH Institutes and Centers (ICs) currently funding this area through their extramural research programs. This analysis of the NIH extramural portfolio in human microbiome research briefly reviews the early history of this field at NIH, summarizes the program objectives and the resources developed in the recently completed 10-year (fiscal years 2007-2016) $215 M Human Microbiome Project (HMP) program, evaluates the scope and range of the $728 M NIH investment in extramural human microbiome research activities outside of the HMP over fiscal years 2012-2016, and highlights some specific areas of research which emerged from this investment. This analysis closes with a few comments on the technical needs and knowledge gaps which remain for this field to be able to advance over the next decade and for the outcomes of this research to be able to progress to microbiome-based interventions for treating disease and supporting health.

References

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Citations

Feb 28, 2019·Microbiome·UNKNOWN 2017 NIH-wide microbiome workshop writing team
Mar 2, 2019·Journal of Medical Internet Research·David D McManusJoanne M Murabito
Mar 16, 2019·Nature Communications·Andrew CaplinGeorge Thurston
Jun 12, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sandra S-J LeeDavid Magnus
Jan 16, 2019·Pharmacotherapy·Gretchen L SachaIshaq Lat
Mar 29, 2019·AORN Journal·Kerri Ubaldi
Apr 10, 2019·Journal of Medical Internet Research·Meredith Elana GiulianiJennifer Michelle Jones
Jul 26, 2019·Addiction·Abigail S FriedmanJody L Sindelar
Jan 21, 2020·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Pilar N Ossorio, Yao Zhou
May 21, 2020·Journal of Dental Research·N S Jakubovics, W Shi
Jul 21, 2020·The American Journal of Clinical Nutrition·Sheila E FleischhackerDariush Mozaffarian
Feb 20, 2020·BMC Bioinformatics·Mrinmoy DasIan B Jeffery
Apr 2, 2020·Frontiers in Immunology·Salwan Al-NasiryBoris W Kramer
Jul 9, 2020·Frontiers in Medicine·Alice RouanetMagali Cordaillat-Simmons
Nov 2, 2019·International Journal of Molecular Sciences·Xinmin Ren, Xiangdong Li
May 31, 2019·Nature·UNKNOWN Integrative HMP (iHMP) Research Network Consortium
Mar 17, 2020·Protein & Cell·Danyi LiJun Wang
Dec 16, 2019·Journal of Neuroinflammation·Kazi Farhana Afroz, Karina Alviña
May 1, 2020·Nature Reviews. Microbiology·Elisha M Wood-CharlsonEmiley A Eloe-Fadrosh
Feb 28, 2020·Clinical Microbiology Reviews·Olivier VandenbergAlex van Belkum
Oct 14, 2020·BMC Medical Informatics and Decision Making·Jasminka Hasic Telalovic, Azra Music
Oct 5, 2020·FEBS Letters·Paolo Riccio, Rocco Rossano
Oct 21, 2020·Nucleic Acids Research·Giorgos SkoufosArtemis G Hatzigeorgiou
Nov 28, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christopher J Hernandez
Oct 9, 2020·Genome Génome / Conseil National De Recherches Canada·Harpreet KaurRaja B Singh
Oct 14, 2020·Annual Review of Pharmacology and Toxicology·Saad KhanLibusha Kelly
Dec 29, 2020·Computational and Structural Biotechnology Journal·Nicholas A BokulichBenjamin D Kaehler
Nov 5, 2019·Advances in Colloid and Interface Science·Adi SeifertYoav D Livney
Dec 12, 2020·Forensic Science International. Genetics·Mirna GhemrawiBruce McCord
Dec 17, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Armen A GhazarianLeah E Mechanic
Apr 3, 2021·Annual Review of Public Health·Jiyoung Ahn, Richard B Hayes
Apr 16, 2021·PLoS Pathogens·Giorgia MoriAntje Blumenthal

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Methods Mentioned

BETA
whole genome shotgun
whole genome
biopsies
biopsy

Software Mentioned

Depicts
HMP
NHMPAG
HMP Data Analysis and Coordination Center ( DACC )
iHMP

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