A review of 241 subjects who were patch tested twice: could fragrance mix I cause active sensitization?

The British Journal of Dermatology
J M L WhiteI R White

Abstract

Active patch test sensitization is an uncommon phenomenon which may have undesirable consequences for those undergoing this gold-standard investigation for contact allergy. To perform a retrospective analysis of the results of 241 subjects who were patch tested twice in a monocentre evaluating approximately 1500 subjects per year. Positivity to 11 common allergens in the recommended Baseline Series of contact allergens (European) was analysed: nickel sulphate; Myroxylon pereirae; fragrance mix I; para-phenylenediamine; colophonium; epoxy resin; neomycin; quaternium-15; thiuram mix; sesquiterpene lactone mix; and para-tert-butylphenol resin. Only fragrance mix I gave a statistically significant, increased rate of positivity on the second reading compared with the first (P=0.011). This trend was maintained when separately analysing a subgroup of 42 subjects who had been repeat patch tested within 1 year; this analysis was done to minimize the potential confounding factor of increased usage of fragrances with a wide interval between both tests. To reduce the confounding effect of age on our data, we calculated expected frequencies of positivity to fragrance mix I based on previously published data from our centre. This showed a ma...Continue Reading

References

Jan 1, 1988·Contact Dermatitis·L KanervaR Jolanki
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Jan 1, 1981·Contact Dermatitis·S Fregert
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Sep 9, 2006·Contact Dermatitis·Donna A Thompson, Boon B Tan
Jul 14, 2007·Contact Dermatitis·Berit Christina CarlsenJeanne Duus Johansen

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Citations

Jun 25, 2010·Contact Dermatitis·Laura CuestaIrene Ballester
Sep 4, 2015·Contact Dermatitis·Johannes GeierWolfgang Uter
May 18, 2016·Journal of the American Academy of Dermatology·Christen M MowadBruce Brod
May 22, 2010·International Journal of Toxicology·Lillian C BeckerF Alan Andersen
Apr 1, 2018·Contact Dermatitis·Lina HagvallAnn-Therese Karlberg
Feb 2, 2021·Current Treatment Options in Allergy·María-Antonia Pastor-Nieto, María-Elena Gatica-Ortega

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