A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors

Journal of Community Genetics
Muni RubensJessy G Dévieux

Abstract

Alcohol use and sexual risk behaviors are multidimensional phenomena involving many genetic and environmental factors. 5-HT transporter linked promoter region (5-HTTLPR) polymorphism constitutes an important factor affecting alcohol use problems and risky sexual behaviors. This paper narratively reviews studies on 5-HTTLPR polymorphism and its associations with alcohol use problems and sexual risk behaviors. We searched the electronic databases, PubMed, Ovid, and Google Scholar for articles using MeSH terms. Relevant articles were reviewed and eligible articles were selected for the study. Many studies have reported a significant but moderate association between 5-HTTLPR polymorphism and alcohol use problems. These studies have implicated the presence of at least one S allele to be associated with significant increases in alcohol use problems. Similarly, some studies associate the S allele with increased sexual risk behaviors. Effective alcohol cessation initiatives and STI/HIV prevention programs should be modified to account for 5-HTTLPR polymorphism before planning interventions; genetic effects could moderate the intervention effect.

References

Apr 24, 1987·Science·C R Cloninger
Jan 1, 1994·Journal of Neural Transmission. General Section·K P LeschP Riederer
Jun 1, 1996·Journal of Neurochemistry·A HeilsK P Lesch
Jan 1, 1995·Journal of Neural Transmission. General Section·A HeilsK P Lesch
Mar 24, 1999·Molecular Psychiatry·E MichaelovskyR Weizman
Jun 27, 2000·Psychopharmacology·B A Johnson, N Ait-Daoud
Aug 26, 2000·Biological Psychiatry·P GorwoodC Boni
Dec 13, 2000·Alcohol·M D ThompsonB F O'Dowd
Mar 10, 2001·Alcoholism, Clinical and Experimental Research·R PastorelliD Palli
May 1, 2001·Alcoholism, Clinical and Experimental Research·A HeinzD Goldman
Jul 13, 2001·American Journal of Medical Genetics·S MatsushitaS Higuchi
Dec 1, 2001·Journal of Substance Abuse Treatment·V ReesJ Samet
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel HoyerGraeme R Martin
Aug 14, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Aryeh I HermanPaolo B Depetrillo
Sep 25, 2003·Alcoholism, Clinical and Experimental Research·Maggie NellisseryHenry R Kranzler
Nov 18, 2003·Nature Reviews. Neuroscience·Patricia GasparLuc Maroteaux
Aug 20, 2004·Alcoholism, Clinical and Experimental Research·Tamiko KonishiYu-Jui Yvonne Wan
Oct 1, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Abdalla Bowirrat, Marlene Oscar-Berman
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aryeh I HermanPaolo B DePetrillo
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Richard FeinnHenry R Kranzler
Jan 18, 2005·Alcoholism, Clinical and Experimental Research·Xianzhang HuMarc A Schuckit
Apr 5, 2005·Journal of Psychiatric Research·Yong Sil KweonChi Un Pae
Apr 19, 2005·Alcoholism, Clinical and Experimental Research·Kent W NilssonLars Oreland
Jun 14, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Klaus Peter Lesch, Lise Gutknecht
Nov 30, 2005·Journal of Psychiatric Research·Stefan Viktor VormfeldeEric Leibing
Aug 18, 2006·Psychiatry Research·Charles S Carver, Christopher J Miller
Feb 1, 2007·Prevention Science : the Official Journal of the Society for Prevention Research·Seth C KalichmanSean Jooste

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Citations

May 11, 2016·Alcoholism, Clinical and Experimental Research·Catherine A MarcinkiewczThomas L Kash
Jan 6, 2017·Journal of Neural Transmission·Lars OrelandErika Comasco

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