A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers

Journal of Psychopharmacology
G J H Dumont, R J Verkes

Abstract

This review of the literature aims to identify the acute effects of MDMA (ecstasy) in healthy volunteers. The wide range of relevant but methodologically diverse tests was .rst grouped into clusters to allow an evaluation of tests that would otherwise have been excluded due to their low frequency of utilization. The following three types of tests were evaluated: (1) functional tests quantifying executive, attention, visual, motor, visuomotor and auditory functions, (2) phenomenological tests assessing personal, subjective experiences, and (3) physiological measures reflecting neurophysiological, endocrine and physiological parameters. MDMA showed robust effects on most of the phenomenological and physiological tests. Functional tests were scarce, preventing any meaningful conclusions to be drawn from their evaluation other than that these tests should be incorporated into future acute-effect studies. A striking doseñresponse relationship appeared for cardiovascular effects. At doses below 1.0 mg/kg MDMA no change was observed relative to placebo while above this dose all studies reported significant increases. Furthermore, pupil size, plasma cortisol and plasma prolactin levels proved responsive to MDMA administration. The repo...Continue Reading

Associated Clinical Trials

References

Jan 1, 1990·Annals of the New York Academy of Sciences·D E Nichols, R Oberlender
Oct 27, 1998·Drug and Alcohol Dependence·F SchifanoR Bricolo
Mar 25, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E LiechtiF X Vollenweider
Jun 29, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M E Liechti, F X Vollenweider
Sep 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A GammaD Hell
Sep 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E LiechtiF X Vollenweider
Nov 21, 2000·Annals of the New York Academy of Sciences·R PacificiR de la Torre
Nov 21, 2000·Annals of the New York Academy of Sciences· de la Torre RJ Cami
Feb 13, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E LiechtiF X Vollenweider
Feb 24, 2001·Psychopharmacology·R J VerkesA F Cohen
Mar 22, 2001·British Journal of Clinical Pharmacology·S J de VisserJ M van Gerven
Apr 21, 2001·Psychopharmacology·M E LiechtiF X Vollenweider
Oct 2, 2001·The American Journal of Psychiatry·R J CroftJ H Gruzelier
Nov 21, 2001·Drug and Alcohol Dependence·M E Tancer, C E Johanson
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Cándido Hernández-LópezRafael de La Torre
Aug 13, 2002·Psychopharmacology·Debra S HarrisReese T Jones
Sep 6, 2002·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Samantha R GrossRobert O Pihl
Oct 31, 2002·Human Psychopharmacology·Liesbeth RenemanGerard J. Den Heeten
Oct 31, 2002·Human Psychopharmacology·Matthias E. Liechti, Franz X. Vollenweider
Jan 22, 2003·British Journal of Clinical Pharmacology·S J de VisserJ M A van Gerven
Apr 15, 2003·Journal of Psychoactive Drugs·Franz X VollenweiderMark Geyer
May 27, 2003·Human Psychopharmacology·Marinus N Verbaten
Jul 19, 2003·Pharmacological Reviews·A Richard GreenM Isabel Colado
Aug 21, 2003·Forensic Science International : Synergy·R García-RepettoM Menéndez
Oct 18, 2003·Drug and Alcohol Dependence·Manuel Tancer, Chris-Ellyn Johanson
Jan 15, 2004·The Journal of Pharmacology and Experimental Therapeutics·Roberta PacificiRafael de la Torre
Jan 22, 2004·Psychopharmacology·Elizabeth Anne JohnsonDiane B Miller
Feb 21, 2004·International Journal of Cardiology·Paula RaviñaTomas Raviña
Apr 15, 2004·Psychopharmacology·M Isabel ColadoA Richard Green
Sep 17, 2004·Psychopharmacology·Jörg DaumannEuphrosyne Gouzoulis-Mayfrank
Oct 7, 2004·European Journal of Pharmacology·A Richard GreenM Isabel Colado
Dec 17, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Edward M MillsJon E Sprague

❮ Previous
Next ❯

Citations

Aug 15, 2009·Psychopharmacology·Gillinder BediHarriet de Wit
Jul 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Boris MlinarRenato Corradetti
Jul 18, 2008·Social Neuroscience·M R ThompsonI S McGregor
Oct 10, 2008·Brain : a Journal of Neurology·Maartje M L de WinWim van den Brink
Oct 23, 2013·European Journal of Psychotraumatology·Rianne A de KleineAgnes van Minnen
Feb 9, 2016·Neuroscience and Biobehavioral Reviews·Carl Alexander RobertsCatharine Montgomery
Jan 10, 2016·Neuroscience and Biobehavioral Reviews·F MuellerS Borgwardt
Mar 6, 2012·Neurotoxicology and Teratology·Lynn T SingerAndrew C Parrott
Dec 28, 2010·Neuroscience and Biobehavioral Reviews·Susan Schenk
Feb 28, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Murray R ThompsonIain S McGregor
Jan 10, 2009·British Journal of Clinical Pharmacology·Lineke ZuurmanJoop M A van Gerven
Mar 13, 2012·British Journal of Pharmacology·Cm HysekM E Liechti
Feb 3, 2011·British Journal of Clinical Pharmacology·Remco W M ZoethoutJoop M A van Gerven
Sep 29, 2011·Human Psychopharmacology·Claire NulsenGeoff Hammond
Sep 1, 2011·Microscopy Research and Technique·Federica FulceriMarco Gesi
Sep 6, 2012·British Journal of Pharmacology·K P C KuypersJ G Ramaekers
Dec 18, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A C ParrottT Stalder
Dec 20, 2014·Psychopharmacology·Samanta Yubero-LahozRafael de la Torre
Jul 24, 2013·Neuroscience and Biobehavioral Reviews·Desirée B SpronkRobbert J Verkes
May 11, 2013·Neuroscience and Biobehavioral Reviews·Andrew C Parrott
Mar 29, 2014·Neuropharmacology·E B de Sousa Fernandes PernaJ G Ramaekers
Oct 10, 2013·The International Journal of Neuropsychopharmacology·Cédric M HysekMatthias E Liechti
Feb 19, 2011·The International Journal of Neuropsychopharmacology·Maarten van den BuuseVictoria Risbrough
May 15, 2009·Clinical Pharmacology and Therapeutics·G J DumontR J Verkes
May 17, 2014·Journal of Psychoactive Drugs·Andrew C Parrott
Oct 29, 2015·PloS One·Javier Navarro-ZaragozaMaría-Luisa Laorden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.