A review of adjuvant therapy for resected primary gastric cancer with an update on Taegu's phase III trial with intraperitoneal chemotherapy

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Wansik Yu

Abstract

Because patients with advanced gastric cancers have less than 50% chance of cure after R0 resection, the need for an adjuvant treatment to eradicate residual microscopic disease is clear. The major treatment strategy during the last decades has been postoperative systemic therapy. The results of published trials were reviewed. And, perioperative intraperitoneal chemotherapy as an adjuvant to potentially curative surgery was evaluated. A literature search on this topic was performed for articles relating to clinical trials using adjuvant chemotherapy in the management of gastric cancer. Subset analyses of Taegu's phase III trial of early postoperative intraperitoneal chemotherapy were performed. Even after extended lymphadenectomy, the peritoneal surface and resection site had a high incidence of recurrence. Postoperative systemic chemotherapy treatment regimens available in the past showed no major improvement in survival. One of new approaches currently undergoing study was intraperitoneal chemotherapy given in the perioperative period. The Taegu data showed this treatment reduced the incidence of peritoneal recurrence and thereby improved the survival rate after potentially curative surgery for gastric cancer. The eradication...Continue Reading

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Citations

Jul 27, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P Khosravi ShahiG Pérez Manga
Oct 16, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Javier LacuevaJuan Antonio Díaz-González
Jul 21, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Oh Kyoung KwonWansik Yu
Sep 21, 2007·Surgical Oncology·Steven C Cunningham, Richard D Schulick
Aug 30, 2008·Journal of Surgical Oncology·F BozzettiMarcello Deraco
Jan 17, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Roderich E Schwarz
Jul 1, 2020·Journal of Gastric Cancer·Daryl K A Chia, Jimmy B Y So
Sep 19, 2020·Current Atherosclerosis Reports·Peter E Penson, Maciej Banach

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