PMID: 15218407Jun 26, 2004Paper

A review of age differences in the neurophysiology of nociception and the perceptual experience of pain

The Clinical Journal of Pain
Stephen J Gibson, Michael Farrell

Abstract

To better understand the nature of age differences in pain and nociception with the aging of the worlds' population. The evidence from numerous neurophysiologic and psychological studies suggest a small, but demonstrable age-related impairment in the early warning functions of pain. The increase in pain perception threshold and the widespread change in the structure and function of peripheral and CNS nociceptive pathways may place the older person at greater risk of injury. Moreover, the reduced efficacy of endogenous analgesic systems, a decreased tolerance of pain and the slower resolution of postinjury hyperalgesia may make it more difficult for the older adult to cope, once injury has occurred. These age-related changes may be best conceptualized as a reduced capacity in the functional reserve of the pain system, at both ends of the intensity spectrum. The clinical implications are obvious; older persons are likely to be especially vulnerable to the negative impacts of pain and pain associated events.

References

Mar 26, 1977·Lancet·P WhiteD M Bowen
Jul 1, 1977·Journal of Gerontology·S W Harkins, C R Chapman
Sep 1, 1976·Pain·Stephen W Harkins, Richard C Chapman
Mar 1, 1976·Bulletin of Environmental Contamination and Toxicology·B P SmithB J Camp
Dec 31, 1991·Mechanisms of Ageing and Development·F AmentaW L Collier
Jul 1, 1987·Electroencephalography and Clinical Neurophysiology·G M StrainN A O'Malley
Jan 1, 1989·Experimental Aging Research·J S Knisely, R J Hamm
Feb 1, 1989·American Journal of Physical Medicine & Rehabilitation·N E WalshJ Hoffman
Mar 1, 1989·Journal of Neuropathology and Experimental Neurology·C A KnoxP J Dyck
Jan 1, 1986·Annals of the New York Academy of Sciences·L R Watkins, D J Mayer
Dec 1, 1988·Brain Research Bulletin·R J BodnarE Kramer
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Jan 1, 1986·Physiology & Behavior·E Kramer, R J Bodnar
Nov 1, 1986·Journal of Gerontology·D R Kenshalo
Jan 1, 1986·Journal of Gerontology·S W HarkinsM Martelli
May 1, 1985·Pain·C R ChapmanA E Reading
Jun 1, 1985·Pain·L V Laitinen, A T Eriksson
Oct 1, 1985·Annals of Neurology·R D Helme, S McKernan
Dec 1, 1985·Brain : a Journal of Neurology·J M Jacobs, S Love
Oct 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·D J O'Sullivan, M Swallow
Nov 1, 1972·Psychosomatic Medicine·K M WoodrowM F Collen
Nov 1, 1965·Archives of Oral Biology·J M Mumford
Jan 1, 1970·Gerontologia Clinica·P ProcacciM Della Corte
Jan 1, 1994·Journal of the Autonomic Nervous System·T A Abdel-Rahman, T Cowen
Apr 4, 1994·Brain Research·Z KhalilR D Helme
Nov 1, 1994·Neurochemical Research·H L Fernandez, C A Hodges-Savola
Mar 1, 1995·Pain·D YarnitskyJ A Hemli
Dec 20, 1994·Journal of the Neurological Sciences·D Meh, M Denislic
Nov 1, 1995·Pain·M WeisenbergJ Schwarzwald

❮ Previous
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Citations

Jun 1, 2005·Tijdschrift voor gerontologie en geriatrie·E J A ScherderD F Swaab
Nov 18, 2010·Journal of Neurology·Sandro Zambito MarsalaGiovanni Defazio
Jul 24, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Hiroki NagaiKazuhiro Yanagihara
May 7, 2011·Journal of Anesthesia·Vassilios TassoudisGeorge Tzovaras
May 20, 2008·British Journal of Anaesthesia·J F KarpD K Weiner
Feb 27, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R P YezierskiC J Vierck
Dec 24, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Drake MorganChristy S Carter
Jul 21, 2005·Regional Anesthesia and Pain Medicine·Frédéric Aubrun
Aug 21, 2009·The Clinical Journal of Pain·Amy WachholtzHoward Eisenson
Nov 19, 2009·The Clinical Journal of Pain·Sureeporn UthaikhupGwendolen Jull
Feb 27, 2013·Journal of Strength and Conditioning Research·Cristina CortisLaura Capranica
Aug 31, 2007·Drugs & Aging·Sebastiano Mercadante, Edoardo Arcuri
Mar 29, 2014·Ageing Research Reviews·Sibylle PetersenOmer Van den Bergh
Jun 1, 2014·Brain Research·Ali EzzatiRichard B Lipton
Dec 7, 2010·Annual Review of Clinical Psychology·Robert D KernsBurel R Goodin
Nov 24, 2011·Pain Research and Treatment·Yannick Tousignant-Laflamme, Serge Marchand
Jun 15, 2014·Age and Ageing·Felicity C VealGregory M Peterson
Jan 16, 2014·Hand : Official Journal of the American Association for Hand Surgery·Alessandro ChiarottoJorge Hugo Villafañe
Aug 1, 2013·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·T TecicE Neugebauer
Jul 21, 2009·Expert Opinion on Drug Safety·Joseph V PergolizziErrol Gould
Sep 26, 2006·Scandinavian Journal of Rheumatology. Supplement·T Graven-Nielsen
May 23, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jonathan Bruce Barber, Stephen J Gibson
Feb 22, 2016·Current Pain and Headache Reports·Mark R JonesAlan D Kaye
Apr 6, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Inmaculada RiquelmePedro Montoya
Apr 25, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michael J Farrell
Apr 25, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Robert P Yezierski
Apr 25, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Benny Katz
Apr 25, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Stefan Lautenbacher
Aug 25, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michael Farrell, Stephen Gibson
Feb 27, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Felicity C VealGregory M Peterson
Jun 8, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Youjie ZhangZengnan Mo
Jun 28, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Alessandro ChiarottoJorge Hugo Villafañe
Dec 7, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Kelly M NaugleJoseph L Riley
Jan 28, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Matthew D JonesBenjamin K Barry
Jan 28, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Hailey W BullsLaurence A Bradley
Nov 26, 2015·International Journal of Molecular Sciences·Tanya S King-HimmelreichEllen Niederberger
Nov 17, 2012·The Surgical Clinics of North America·Larry Lindenbaum, David J Milia
Dec 7, 2011·The Journal of Pain : Official Journal of the American Pain Society·Joel D GreenspanWilliam Maixner
Sep 20, 2011·Best Practice & Research. Clinical Anaesthesiology·Julia C ColdreyPamela E Macintyre
Mar 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Dane B CookLaura D Ellingson
Mar 23, 2010·Annals of Emergency Medicine·Polly E BijurE John Gallagher
Dec 17, 2009·Surgical Oncology·Chiara Catananti, Giovanni Gambassi

❮ Previous
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