A review of albumin binding in CKD

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Björn MeijersPieter Evenepoel

Abstract

Hypoalbuminemia is associated with excess mortality in patients with kidney disease. Albumin is an important oxidant scavenger and an abundant carrier protein for numerous endogenous and exogenous compounds. Several specific binding sites for anionic, neutral, and cationic ligands were described. Overall, the extent of binding depends on the ligand and albumin concentration, albumin-binding affinity, and presence of competing ligands. Chronic kidney disease affects all these determinants. This may result in altered pharmacokinetics and increased risk of toxicity. Renal clearance of albumin-bound solutes mainly depends on tubular clearance. Dialytic clearance by means of conventional hemodialysis/hemofiltration and peritoneal dialysis is limited. Other epuration techniques combining hemodialysis with adsorption have been developed. However, the benefit of these techniques remains to be proved.

References

Jan 1, 1992·European Journal of Clinical Pharmacology·T J DenglerH J Dengler
May 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E G Lowrie, N L Lew
Jan 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H MabuchiT Oka
May 1, 1988·Kidney International·R VanholderS Ringoir
Jul 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Mabuchi, H Nakahashi
Feb 1, 1986·Archives of Toxicology·J H RommesA N van Heijst
May 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P F Gulyassy, T A Depner
Jan 1, 1984·Acta Pharmacologica Et Toxicologica·B Beermann
Jan 1, 1993·European Journal of Clinical Pharmacology·I Janků
Dec 1, 1995·Biological & Pharmaceutical Bulletin·T SakaiM Otagiri
Sep 1, 1996·Human & Experimental Toxicology·T Y Chan
Dec 16, 1997·Mineral and Electrolyte Metabolism·G A Kaysen
Jul 1, 1998·Clinical Pharmacokinetics·R KirstenB Heintz
Jul 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E MovilliR Maiorca
Oct 10, 1998·Kidney International·M ArnadottirE Dimény
Dec 23, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G LesafferR Vanholder
Mar 11, 2000·American Journal of Hypertension·S Oparil
Aug 5, 2000·American Journal of Physiology. Renal Physiology·R A Van AubelF G Russel
Aug 11, 2000·Kidney International. Supplement·J BotellaC Sanz-Moreno
Oct 24, 2000·Kidney International·P J ThornalleyA Dawnay
May 23, 2001·Clinical Pharmacokinetics·P E Wallemacq, R K Verbeeck
May 24, 2001·The Journal of Biological Chemistry·S SenguptaD W Jacobsen
Jul 24, 2001·Pharmaceutical Research·M AnrakuM Otagiri
Jul 31, 2001·JAMA : the Journal of the American Medical Association·H C GersteinUNKNOWN HOPE Study Investigators
Aug 29, 2001·Clinical Pharmacokinetics·K Mahalati, B D Kahan
Mar 22, 2002·Clinical Pharmacology and Therapeutics·Leslie Z Benet, Betty-ann Hoener
Apr 3, 2002·Advances in Renal Replacement Therapy·James F Winchester
Jun 27, 2002·Clinical Pharmacokinetics·William H Frishman, Mamata Alwarshetty
Jul 20, 2002·Clinical Pharmacokinetics·Fatemeh Akhlaghi, Andrew K Trull
Oct 3, 2002·Circulation·Hans L HillegeUNKNOWN Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group
Oct 10, 2002·Kidney International·Jonathan HimmelfarbRaymond M Hakim
Dec 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Amitava Dasgupta

❮ Previous
Next ❯

Citations

Aug 21, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Björn K I MeijersPieter Evenepoel
Nov 17, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sebastian KlammtSteffen Mitzner
Jan 11, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tammy L SirichTimothy W Meyer
Oct 17, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Björn K I MeijersPieter Evenepoel
Feb 10, 2012·Kidney International·Timothy W Meyer, Thomas H Hostetter
Dec 1, 2009·Kidney International. Supplement·Pieter EvenepoelKristin Verbeke
Aug 17, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nita A LimdiT Mark Beasley
Aug 28, 2009·Seminars in Dialysis·Noémie Jourde-ChichePhilippe Brunet
Sep 21, 2011·Seminars in Dialysis·Timothy W MeyerThomas H Hostetter
Jan 10, 2013·Biopharmaceutics & Drug Disposition·Liesbeth ViaeneBjörn Meijers
Sep 13, 2015·Transplantation Proceedings·G LigabueG Cappelli
Apr 17, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Ruben PoesenBjörn Meijers
May 7, 2013·Korean journal of pediatrics·Hye Sun HyunHee Yeon Cho
Aug 5, 2015·PloS One·Clara BarriosCristina Menni
Nov 2, 2016·Journal of the American Society of Nephrology : JASN·Ruben PoesenBjörn Meijers
Jun 1, 2016·Geriatrics & Gerontology International·Aleksandra Wyczalkowska-TomasikLeszek Paczek
Nov 17, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pieter EvenepoelBjörn Meijers
Mar 15, 2018·American Journal of Physiology. Renal Physiology·James G AthertonErnő Lindner
May 16, 2018·Nature Reviews. Nephrology·Tao YangMohan K Raizada
Feb 28, 2014·Journal of Materials Science. Materials in Medicine·Susan R SandemanSergey V Mikhalovsky
Feb 14, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Magdalena MaderoPeter Kotanko
Jul 3, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Ruben PoesenBjörn Meijers
May 10, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yuanyuan ShiFeng Ding
May 28, 2017·The Journal of Pharmacology and Experimental Therapeutics·Toshihiro SatoHiroaki Yamaguchi
Sep 21, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kristine HoleEspen Molden
Jul 2, 2017·Clinical Science·Jitske JansenRosalinde Masereeuw
Nov 2, 2013·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Liesbeth ViaenePieter Evenepoel
Apr 2, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Peter B Soeters
Jun 25, 2020·Small·Hèctor López-LagunaEsther Vázquez
Jan 27, 2019·Experimental Biology and Medicine·Mark A BryniarskiRabi Yacoub
Apr 24, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Li QingpingChen Xiangmei

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.