A Review of Antibiotic Use in Pregnancy

Pharmacotherapy
P Brandon BookstaverMilena McLaughlin

Abstract

During pregnancy, untreated sexually transmitted or urinary tract infections are associated with significant morbidity, including low birth weight, preterm birth, and spontaneous abortion. Approximately one in four women will be prescribed an antibiotic during pregnancy, accounting for nearly 80% of prescription medications in pregnant women. Antibiotic exposures during pregnancy have been associated with both short-term (e.g., congenital abnormalities) and long-term effects (e.g., changes in gut microbiome, asthma, atopic dermatitis) in the newborn. However, it is estimated that only 10% of medications have sufficient data related to safe and effective use in pregnancy. Antibiotics such as beta-lactams, vancomycin, nitrofurantoin, metronidazole, clindamycin, and fosfomycin are generally considered safe and effective in pregnancy. Fluoroquinolones and tetracyclines are generally avoided in pregnancy. Physiologic changes in pregnancy lead to an increase in glomerular filtration rate, increase in total body volume, and enhanced cardiac output. These changes may lead to pharmacokinetic alterations in antibiotics that require dose adjustment or careful monitoring and assessment.

References

Oct 1, 1989·American Journal of Obstetrics and Gynecology·M P ReyesW Rintelmann
May 1, 1985·Reviews of Infectious Diseases·A W Chow, P J Jewesson
Nov 1, 1995·American Journal of Obstetrics and Gynecology·M R JoesoefB Utomo
Mar 1, 1995·Clinical Pharmacokinetics·G M Pacifici, R Nottoli
Jan 16, 1999·American Journal of Perinatology·A EinarsonG Koren
May 8, 2001·Pharmacoepidemiology and Drug Safety·C R DrinkardJ Clouse
Jul 11, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·G Bothamley
Jul 17, 2001·Seminars in Perinatology·M C Frederiksen
Aug 25, 2001·The New England Journal of Medicine·M A KlebanoffUNKNOWN National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units
May 29, 2003·American Journal of Respiratory and Critical Care Medicine·Mike Thomas, David Price
Jan 13, 2004·Clinics in Perinatology·Patrick S Ramsey, William W Andrews
May 24, 2005·Reproductive Toxicology·Z KazyA E Czeizel
Sep 24, 2005·Clinical Pharmacokinetics·Gail D Anderson
Dec 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Zoltán KazyAndrew E Czeizel
Jun 1, 2006·BMC Pregnancy and Childbirth·Moumita SarkarAdrienne R N Einarson
Aug 3, 2006·International Journal of Occupational Medicine and Environmental Health·Wiesław JedrychowskiFrederica Perera
Aug 5, 2008·Clinical Obstetrics and Gynecology·Kristy Ward, Regan N Theiler
Dec 17, 2009·British Journal of Clinical Pharmacology·Ilan MatokAmalia Levy
Feb 2, 2010·Pharmacoepidemiology and Drug Safety·Fabiano SantosAnick Bérard
Feb 27, 2010·Anesthesia and Analgesia·Marco MercieriRoberto Arcioni
Mar 4, 2010·The Annals of Pharmacotherapy·Jeffrey S StroupTerry Badzinski
Jul 14, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·F SantosA Berard
Jul 19, 2011·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Margaret P AdamJ M Friedman
Nov 30, 2011·Pharmacoepidemiology and Drug Safety·Ditte Mølgaard-Nielsen, Anders Hviid
Jul 4, 2012·Antimicrobial Agents and Chemotherapy·Catherine A KossEmilia H Koumans
Jul 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pamela SearsKarl Weiss
Nov 13, 2012·The Journal of Pediatrics·Lone Graff StensballeHans Bisgaard
Dec 21, 2012·American Journal of Obstetrics and Gynecology·Kueiyu Joshua LinSonia Hernández-Díaz
Mar 12, 2013·Obstetrics and Gynecology International·Jon Trærup AndersenHenrik Enghusen Poulsen
Apr 24, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A C VidalC Hoyo
May 8, 2013·Antimicrobial Agents and Chemotherapy·Anat Bahat DinurAmalia Levy
Aug 6, 2013·Pharmacoepidemiology and Drug Safety·Linda de JongeMarian K Bakker
Dec 20, 2013·European Journal of Clinical Pharmacology·Bengt Källén, Bengt R Danielsson
Jan 1, 2011·Journal of the Turkish German Gynecological Association·Mukesh Kumar JaiswalYogesh Kumar Jaiswal
Apr 29, 2014·Frontiers in Pharmacology·Maged M Costantine
May 3, 2014·BMJ Case Reports·Lidewij van de MheenEline S A van den Akker
Oct 10, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N T MuellerA Rundle
Nov 20, 2014·BMC Infectious Diseases·Hang Thanh NguyenMaurizio Bonati
Nov 20, 2014·Obstetrical & Gynecological Survey·Enav YefetZohar Nachum
Dec 24, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Brittany LapinVictoria Persky
Jan 18, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Ashley F HarbisonMegan E Musselman
Mar 15, 2015·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Ori GoldbergGideon Koren

❮ Previous
Next ❯

Citations

Jun 18, 2016·BMC Medicine·Amir A Kuperman, Omry Koren
Sep 8, 2016·The New England Journal of Medicine·Richard M Rosenfeld
Nov 29, 2017·The Journal of Antimicrobial Chemotherapy·Hélène PeyriereJacques Reynes
Mar 10, 2018·The Annals of Pharmacotherapy·Brooke L GriffinAnahit Simonyan
Jul 20, 2018·Research in Nursing & Health·Jordan R MurphyElizabeth J Corwin
Mar 22, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Thaís Romera BergamoRachel Riera
Jun 16, 2017·Journal of Clinical Microbiology·S JorgensenA Wong-Beringer
Dec 18, 2018·The Annals of Pharmacotherapy·Hana RacP Brandon Bookstaver
Dec 5, 2018·Pharmacotherapy·Kristy M ShaeerJonathan C Cho
Apr 22, 2018·The European Respiratory Journal·Keely LoewenMeghan B Azad
Jul 6, 2018·The European Respiratory Journal·Mingyu ZhangNoel T Mueller
Feb 8, 2019·European Journal of Dental Education : Official Journal of the Association for Dental Education in Europe·Izabela StruzyckaWaleria Hryniewicz
Mar 22, 2019·Current Pharmaceutical Design·André DallmannKarel Allegaert
Aug 10, 2019·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Smriti RaichandAlys Havard
Jan 30, 2018·Frontiers in Microbiology·Lucy L FurfaroMatthew S Payne
Nov 14, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Narmeen MallahBahi Takkouche
Sep 5, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·C MannucciG Calapai
Jan 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kedir N TuriPingsheng Wu
Dec 15, 2016·Frontiers in Medicine·Douglas B Kell, Louise C Kenny
Apr 18, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Mario PassaroGiancarlo Balbi
Jan 31, 2020·Obstetrical & Gynecological Survey·Daniel SpinosaSarah Dotters-Katz
Jan 23, 2018·Frontiers in Medicine·Louise C Kenny, Douglas B Kell
Jan 19, 2019·Molecular and Clinical Oncology·Merav BarzilaiOdelia Amit
Aug 28, 2020·Nature Reviews. Urology·Florian M E WagenlehnerZafer Tandogdu
Sep 11, 2019·The Journal of Antimicrobial Chemotherapy·Thijs Ten DoesschateCornelis H van Werkhoven
Jun 18, 2020·Journal of Inflammation Research·Sedigheh HantoushzadehAmir Hossein Norooznezhad
Apr 29, 2020·American Journal of Obstetrics and Gynecology·Meredith A KelleherIrina Burd
Jan 15, 2021·Journal of Pharmaceutical Policy and Practice·Mohamed A BarakaZaheer-Ud-Din Babar
Feb 4, 2021·Infectious Diseases in Obstetrics and Gynecology·Amanda WangSarah Villarreal
Mar 20, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Claudia Castruita-De la RosaMargarita L Martinez-Fierro
Dec 19, 2020·Microorganisms·Mohammed AmirMelody Y Zeng
Jan 29, 2021·Infection and Drug Resistance·Tigist GashawFirehiwot Amare
Jan 26, 2021·Geburtshilfe und Frauenheilkunde·Marcelo Borges CavalcanteEdward Araujo Júnior
Feb 15, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Camille LenoirVictoria Rollason

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

© 2021 Meta ULC. All rights reserved