A Review of Antipsychotics and Priapism.

Sexual Medicine Reviews
Thomas HwangHossein Sadeghi-Nejad

Abstract

Pharmacologically induced priapism is now the most common cause of priapism, with approximately 50% of drug-related priapism being attributed to antipsychotic usage. The majority of pharmacologic priapism is believed to result in ischemic priapism (low flow), which may lead to irreversible complications, such as erectile dysfunction. It is imperative that prescribing physicians be aware of potentially inciting medications. To identify medications, specifically antipsychotics, associated with priapism and prolonged erections and understand the rates and treatment of these side effects. A PubMed search of all articles available on the database relating to priapism, prolonged erections, and antipsychotics was performed. Various typical and atypical antipsychotic drugs (APDs) have been implicated in pharmacologically induced priapism. In addition to dopaminergic and serotoninergic receptors, APDs have affinities for a wide array of other receptors in the central nervous system, including histaminergic, noradrenergic, and cholinergic receptors. Although the exact mechanism is unknown, the most commonly proposed mechanism of priapism associated with APDs is α-adrenergic blockade in the corpora cavernosa of the penis. Priapism appears...Continue Reading

References

Sep 1, 1989·Annals of Emergency Medicine·W M O'BrienJ H Lynch
Mar 1, 1989·Archives of General Psychiatry·R T Segraves
Jun 1, 1984·The American Journal of Psychiatry·J M LawrenceF H Frankel
Aug 1, 1984·Psychosomatics·S R Griffith, J S Zil
Feb 7, 2001·The American Journal of Psychiatry·M T ComptonS A Berry
Mar 15, 2001·The Journal of Clinical Psychiatry·A Seger, J S Lamberti
Jun 20, 2001·The Journal of Clinical Psychiatry·M T Compton, A H Miller
Dec 1, 2001·The American Journal of Psychiatry·R N BongaleE M Navarro
Feb 13, 2002·Journal of Child and Adolescent Psychopharmacology·T OwleyE H Cook
Apr 3, 2002·The Journal of Clinical Psychiatry·Oliver Freudenreich
Apr 10, 2002·Pharmacotherapy·Larry A DentJenny D Murney
Aug 14, 2002·Pharmacotherapy·Roy R Reeves, James E Mack
Apr 3, 2004·Nature Reviews. Drug Discovery·Bryan L RothWesley K Kroeze
May 12, 2004·Radiologic Clinics of North America·Hossein Sadeghi-NejadMamdouh A Mohamed
May 18, 2004·The Australian and New Zealand Journal of Psychiatry·K JagadheesanSayeed Akhtar
Aug 5, 2004·Psychiatric Services : a Journal of the American Psychiatric Association·Peter J WeidenJulie Locklear
Sep 7, 2004·Journal of Clinical Psychopharmacology·Mihaela Bucur, Tariq Mahmood
Jan 12, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Anissa Abi-Dargham, Marc Laruelle
Jan 15, 2005·Journal of Child and Adolescent Psychopharmacology·Pinchen Yang, Jui-Hsiu Tsai
Jan 18, 2006·Journal of Clinical Psychopharmacology·George HarrisonKimberly Nelson
May 12, 2006·International Clinical Psychopharmacology·Chien-Shu WangFor-Wey Lung
Oct 3, 2007·Mayo Clinic Proceedings·Yen-Yue LinShih-Hung Tsai
Dec 20, 2007·International Clinical Psychopharmacology·Shabnam SoodMaria-Jesus Bailon
Oct 22, 2008·European Urology·David J RalphSukbinder Minhas
Oct 31, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·N BrichartA Mallek
Mar 28, 2009·Atencion primaria·Antonio Luis Aguilar-SheaCristina Gallardo-Mayo
Sep 15, 2009·Primary Care Companion to the Journal of Clinical Psychiatry·Ashish Sharma, Mark H Fleisher
Jan 16, 2010·Journal of Clinical Psychopharmacology·Frank AndersohnEdeltraut Garbe
Jul 8, 2010·International Journal of Emergency Medicine·Matthew J GeraciRajnikant A Patel
May 31, 2011·The Urologic Clinics of North America·Arthur L Burnett, Trinity J Bivalacqua
Nov 8, 2011·Asian Journal of Andrology·Helen R LeveyTrinity J Bivalacqua
Oct 2, 2012·Annual Review of Medicine·Herbert Y Meltzer
Dec 10, 2013·European Urology·Andrea SaloniaUNKNOWN European Association of Urology
Aug 1, 2011·CNS Spectrums·Wen-Yu HsuCheng-Yeh Lin
Mar 3, 2017·Balkan Medical Journal·Hasan Bozkurt, Serkan Şahin
Jul 6, 2017·Current Neuropharmacology·Spyridon SiafisGeorgios Papazisis
Dec 7, 2018·Sexual Medicine Reviews·Nikolas D ScherzerWayne J G Hellstrom

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