A review of applications of metabolomics in osteoarthritis.

Clinical Rheumatology
Jie-Ting LiGuo-Xin Ni

Abstract

Osteoarthritis (OA) represents the most prevalent and disabling arthritis worldwide due to its heterogeneous and progressive articular degradation. However, effective and timely diagnosis and fundamental treatment for this disorder are lacking. Metabolomics, a growing field in life science research in recent years, has the potential to detect many metabolites and thus explains the underlying pathophysiological processes. Hence, new specific metabolic markers and related metabolic pathways can be identified for OA. In this review, we aimed to provide an overview of studies related to the metabolomics of OA in animal models and humans to describe the metabolic changes and related pathways for OA. The present metabolomics studies reveal that the pathogenesis of OA may be significantly related to perturbations of amino acid metabolism. These altered amino acids (e.g., branched-chain amino acids, arginine, and alanine), as well as phospholipids, were identified as potential biomarkers to distinguish patients with OA from healthy individuals.

References

Jul 27, 2000·Medicine and Science in Sports and Exercise·R A BassitL F Costa Rosa
Jan 29, 2002·Best Practice & Research. Clinical Rheumatology·S B AbramsonM Attur
Mar 30, 2005·The Journal of Nutrition·Wenjiang J FuGuoyao Wu
Nov 11, 2005·The American Journal of Clinical Nutrition·Christos S KatsanosRobert R Wolfe
Jan 26, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wei XiaGeorge A C Murrell
Feb 14, 2006·The American Journal of Clinical Nutrition·Sidney M Morris
Jul 1, 2006·Analytical Chemistry·Aalim M WeljieCarolyn M Slupsky
Aug 22, 2006·Mass Spectrometry Reviews·Katja DettmerBruce D Hammock
Jul 31, 2007·International Journal of Cardiology·Chih-Chan LinJyh-Hong Chen
Aug 28, 2007·Journal of Orthopaedic Surgery and Research·Yi ChenAdekunle Oloyede
Apr 3, 2008·Arthritis and Rheumatism·J M Blair-LevyP E Lipsky
Jul 18, 2008·American Journal of Physiology. Cell Physiology·Cindy GustinMartine Raes
Sep 9, 2008·Cell·Elaine HolmesJeremy K Nicholson
Oct 25, 2008·Nature·Jeremy K Nicholson, John C Lindon
Nov 26, 2008·Arthritis Research & Therapy·Steven B Abramson
Apr 15, 2010·Annals of the Rheumatic Diseases·Guangju ZhaiTim D Spector
Dec 2, 2010·Nature Reviews. Rheumatology·Mohit KapoorHassan Fahmi
Dec 21, 2010·Analytica Chimica Acta·D RyanMegan Kendall
Aug 10, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Alexander Y HuiRobert L Sah
Nov 9, 2011·Osteoarthritis and Cartilage·S B AdamsD L Nettles
Mar 7, 2012·Arthritis and Rheumatism·Richard F LoeserMary B Goldring
Dec 13, 2012·Journal of Molecular and Cellular Cardiology·Lisa C HeatherJulian L Griffin
Jun 21, 2013·Arthritis and Rheumatism·Marta Krystyna KosinskaJuergen Steinmeyer
Aug 7, 2013·International Journal of Sport Nutrition and Exercise Metabolism·Jairus J QuesneleGreg D Wells
Dec 18, 2013·Cancer Letters·Aihua ZhangXijun Wang
Feb 14, 2014·The Journal of Nutrition, Health & Aging·K HristinaM Trapecar
Oct 7, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Beata MickiewiczHans J Vogel
Oct 8, 2014·Nature Reviews. Endocrinology·Christopher J Lynch, Sean H Adams
Jan 28, 2015·Clinical Orthopaedics and Related Research·Jeffrey J NeppleJohn C Clohisy
Feb 11, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Thomas MabeySittisak Honsawek
May 27, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Beata MickiewiczHans J Vogel
Jul 17, 2015·British Medical Bulletin·S KluzekN K Arden
Sep 29, 2015·The Journal of Pathology·C Bruce A WhitelawBhanu P Telugu
Dec 29, 2015·Osteoarthritis and Cartilage·Weidong ZhangGuangju Zhai

❮ Previous
Next ❯

Citations

May 8, 2021·International Journal of Rheumatic Diseases·Tze Chin TanYing Ying Leung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Circulation. Cardiovascular Genetics
Susan ChengAmerican Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nu
Annals of Nutrition & Metabolism
Sebastian RauschertChristian Hellmuth
Annals of Medicine
Rigoberto Pallares-MéndezLaura Del Bosque-Plata
© 2021 Meta ULC. All rights reserved