A Review of Applied Aspects of Dealing with Gut Microbiota Impact on Rodent Models

ILAR Journal
Axel Kornerup HansenCamilla Hartmann Friis Hansen

Abstract

The gut microbiota (GM) affects numerous human diseases, as well as rodent models for these. We will review this impact and summarize ways to handle this challenge in animal research. The GM is complex, with the largest fractions being the gram-positive phylum Firmicutes and the gram-negative phylum Bacteroidetes. Other important phyla are the gram-negative phyla Proteobacteria and Verrucomicrobia, and the gram-positive phylum Actinobacteria. GM members influence models for diseases, such as inflammatory bowel diseases, allergies, autoimmunity, cancer, and neuropsychiatric diseases. GM characterization of all individual animals and incorporation of their GM composition in data evaluation may therefore be considered in future protocols. Germfree isolator-housed rodents or rodents made virtually germ free by antibiotic cocktails can be used to study diverse microbial influences on disease expression. Through subsequent inoculation with selected strains or cocktails of microbes, new "defined flora" models can yield valuable knowledge on the impact of the GM, and of specific GM members and their interactions, on important disease phenotypes and mechanisms. Rodent husbandry and microbial quality assurance practices will be important...Continue Reading

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Citations

Aug 26, 2016·Nutrition & Metabolism·Maria KuleckaJerzy Ostrowski
Nov 23, 2016·Scientific Reports·Clement ChanCarol Huang
May 2, 2017·PloS One·Katja Maria BendtsenAxel Kornerup Hansen
May 18, 2019·Laboratory Animals·Axel Kornerup HansenCamilla Hartmann Friis Hansen
Nov 12, 2019·ILAR Journal·R Wayne Barbee, Patricia V Turner
Sep 2, 2015·ILAR Journal·André Bleich, James G Fox
Apr 23, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Shingo TakashimaYasuhiro Fujiwara
Jun 30, 2019·Scientific Reports·Hayley L LetsonGeoffrey P Dobson
Feb 7, 2021·Research in Veterinary Science·Torben Sølbeck RasmussenAxel Kornerup Hansen
Jan 21, 2019·The American Journal of Pathology·Jessica D Hathaway-SchraderChad M Novince
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Stephanie Buchheister, André Bleich

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