A review of cardiovascular toxicity of TiO2 , ZnO and Ag nanoparticles (NPs)

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Yi CaoQianyu Yang

Abstract

To ensure the safe use of nanoparticles (NPs) in modern society, it is necessary and urgent to assess the potential toxicity of NPs. Cardiovascular system is required for the systemic distribution of NPs entering circulation. Therefore, the adverse cardiovascular effects of NPs have gained extensive research interests. Metal based NPs, such as TiO2, ZnO and Ag NPs, are among the most popular NPs found in commercially available products. They may also have potential applications in biomedicine, which could increase their contact with cardiovascular systems. This review aimed at providing an overview about the adverse cardiovascular effects of TiO2, ZnO and Ag NPs. We discussed about the bio-distribution of NPs following different exposure routes. We also discussed about the cardiovascular toxicity of TiO2, ZnO and Ag NPs as assessed by in vivo and in vitro models. The possible mechanisms and contribution of physicochemical properties of metal based NPs were also discussed.

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Citations

Aug 31, 2018·Journal of Applied Toxicology : JAT·Dejian YanYi Cao
Mar 22, 2020·Nanomaterials·Elisabeth EljeElise Rundén-Pran
Sep 5, 2020·International Journal of Nanomedicine·Xia QinChengzhi Chen
Nov 5, 2020·Nanotoxicology·Dominik TaterraKrzysztof A Tomaszewski
Sep 26, 2020·Toxicology Mechanisms and Methods·Yi CaoJiamao Chen
Jul 11, 2021·The Journal of Pharmacy and Pharmacology·Tahereh Zadeh Mehrizi, Sedigheh Amini Kafiabad

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