A review of dengue diagnostics and implications for surveillance and control

Transactions of the Royal Society of Tropical Medicine and Hygiene
Nader RaafatRichard J Maude

Abstract

Dengue is the world's most common arboviral infection, with almost 4 billion people estimated to be living at risk of dengue infection. A recently introduced vaccine is currently recommended only for seropositive individuals in a restricted age range determined by transmission intensity. With no effective dengue vaccine for the general population or any antiviral therapy, dengue control continues to rely heavily on vector control measures. Early and accurate diagnosis is important for guiding appropriate management and for disease surveillance to guide prompt dengue control interventions. However, major uncertainties exist in dengue diagnosis and this has important implications for all three. Dengue can be diagnosed clinically against predefined lists of signs and symptoms and by detection of dengue-specific antibodies, non-structural 1 antigen or viral RNA by reverse transcriptase-polymerase chain reaction. All of these methods have their limitations. This review aims to describe and quantify the advantages, uncertainties and variability of the various diagnostic methods used for dengue and discuss their implications and applications for dengue surveillance and control.

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Citations

Jan 12, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Visula AbeysuriyaSanjay de Mel
Feb 11, 2021·PLoS Neglected Tropical Diseases·Jacqueline Kyungah LimSelidji Todagbe Agnandji
Feb 4, 2021·Memórias do Instituto Oswaldo Cruz·Felipe Campos de Melo IaniMyrian Morato Duarte
Sep 9, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Simon D LyttonLe Huu Song
Mar 5, 2021·PloS One·Neal AlexanderJacqueline K Lim
Sep 1, 2021·Journal of Medical Case Reports·Olga Lucia Agudelo RojasFernando Rosso

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Methods Mentioned

BETA
ELISA
PCR
enzyme-linked immunosorbent assay
ELISAs

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