A review of dupilumab in the treatment of atopic diseases

Human Vaccines & Immunotherapeutics
Quinn ThibodeauxTina Bhutani

Abstract

Dupilumab is a fully human monoclonal IgG4 antibody directed against the alpha subunit of the IL-4 receptor and prevents the signaling of IL-4 and IL-13, two type 2 cytokines known to be important drivers of atopic diseases. In March of 2017, the United States Food and Drug Administration (FDA) approved dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults that is uncontrolled with topical medications, becoming the first biologic agent approved to treat this chronic skin condition. In October of 2018, Dupilumab received approval by the FDA as an add-on maintenance therapy in patients with moderate-to-severe asthma aged 12 years or older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma. This review summarizes the characteristics of dupilumab and the clinical research that has been published to date, including treatment efficacy and adverse events.

References

Sep 26, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M S Schubert
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Stephen T HolgateWilliam R Henderson
Apr 15, 2004·Allergy·Matthew MasoliUNKNOWN Global Initiative for Asthma (GINA) Program
Sep 3, 2010·The Journal of Allergy and Clinical Immunology·Claus BachertKristel Van Steen
Jan 15, 2011·Current Allergy and Asthma Reports·Luke Rudmik, Timothy L Smith
Oct 14, 2011·Journal of Clinical & Cellular Immunology·Eric B Brandt, Umasundari Sivaprasad
May 16, 2012·Allergy and Asthma Proceedings·Sigrid Payne DaVeiga
May 22, 2013·The New England Journal of Medicine·Sally WenzelGianluca Pirozzi
Jul 10, 2014·The New England Journal of Medicine·Lisa A BeckAllen R Radin
Nov 8, 2014·The World Allergy Organization Journal·Claus BachertMichael Blaiss
Feb 6, 2015·Expert Review of Clinical Immunology·Bauke PauwelsClaus Bachert
Jan 19, 2016·Journal of the American Academy of Dermatology·Eric L SimpsonVera Mastey
Feb 3, 2016·JAMA : the Journal of the American Medical Association·Claus BachertE Rand Sutherland
May 11, 2016·American Journal of Respiratory Cell and Molecular Biology·Sally E Wenzel
Oct 4, 2016·The New England Journal of Medicine·Eric L SimpsonUNKNOWN SOLO 1 and SOLO 2 Investigators
Mar 10, 2017·Expert Review of Clinical Immunology·Namita A GandhiNeil M H Graham
Oct 11, 2017·Journal of the American Academy of Dermatology·Patrick Fleming, Aaron M Drucker
Nov 11, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Kevin MurphyMario Castro
Nov 29, 2017·International Immunopharmacology·Zuzhen OuWeikang Zhou
Feb 13, 2018·The Journal of Allergy and Clinical Immunology. in Practice·Andreas WollenbergMarjolein de Bruin-Weller
May 9, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Neil Bhattacharyya, Sapideh Gilani
May 22, 2018·The New England Journal of Medicine·Mario CastroAriel Teper
May 22, 2018·The New England Journal of Medicine·Klaus F RabeAriel Teper
Sep 1, 2018·JAMA Dermatology·Alison D TreisterPeter A Lio
Sep 9, 2018·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyJennifer D D Hamilton
Sep 27, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Mitsuru AdachiGen Tamura

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Citations

Sep 11, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Hani Harb, Talal A Chatila
Nov 30, 2019·Seminars in Immunopathology·Markus F Neurath
Mar 12, 2020·Paediatric Drugs·Amelia LicariGian Luigi Marseglia
Nov 12, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Johannes WohlrabAndreas Wollenberg
Mar 16, 2021·The Open Respiratory Medicine Journal·Mohamed AbuzakoukIrfan Shafiq
Mar 19, 2021·Expert Opinion on Biological Therapy·Stefano PassanisiGiovanni B Pajno
Jun 15, 2021·Journal of the American Academy of Dermatology·Shanthi NarlaEric L Simpson
Oct 10, 2021·Journal of the American Academy of Dermatology·Jashin J WuJacob P Thyssen
May 15, 2021·Minerva medica·Ahmed Edris, Lies Lahousse

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Clinical Trials Mentioned

NCT01859988
NCT01312961
NCT01854047
NCT02528214
NCT02414854
NCT01920893
NCT02612454
NCT03054428
NCT03560466
NCT02948959

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