A review of European guidelines on periconceptional folic acid supplementation

European Journal of Clinical Nutrition
Shona CawleyMichael J Turner

Abstract

Strong evidence that folic acid (FA) prevents the majority of cases of neural tube defects (NTDs) has led to national organisations developing guidelines for women concerning periconceptional supplementation. In Europe, there is evidence of national variations in the incidence of NTDs, with a recent Irish study reporting an increase in the rate. This review compares the periconceptional FA supplementation guidelines between the different countries in Europe. An online search of country-specific guidelines produced before 2015 concerning periconceptional FA supplementation was conducted. If an English version was not available directly, the EUROCAT register was searched for the English version of the recommendations. We identified national guidelines from 20 European countries. Over half recommended that FA supplements be taken by women planning a pregnancy, but three recommended that they should be taken by all women of child-bearing age. Four guidelines recommended starting FA at least 4 weeks preconceptionally, but no country recommended starting FA at least 12 weeks preconceptionally as suggested by recently published studies. There is a need for further consideration of the duration of preconceptional FA supplementation spe...Continue Reading

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Citations

Jun 8, 2017·Nutrition Research Reviews·Silvia MaffoniHellas Cena
Mar 14, 2018·Annals of the New York Academy of Sciences·Vijaya Kancherla, Robert E Black
Oct 24, 2017·Journal of Public Health·Shona CawleyMichael J Turner
Oct 17, 2017·Frontiers in Cell and Developmental Biology·Trine StrandgaardKarin Lykke-Hartmann
Apr 17, 2018·Advances in Nutrition·David J Mela, Elizabeth M Woolner
Jul 8, 2020·Nutrients·Alessandra VezzoliRoberto Accinni
Sep 30, 2016·Journal of Public Health·Laura MullaneyMichael J Turner
Nov 3, 2016·European Journal of Clinical Nutrition·S CawleyM J Turner
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Feb 6, 2021·Nutrients·Elvira VerduciGian Vincenzo Zuccotti
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Apr 3, 2020·Current Vascular Pharmacology·Alfonso MateCarmen M Vázquez
Aug 4, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Alfonso MateCarmen M Vázquez

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