PMID: 2493080Feb 1, 1989Paper

A review of experimental studies of iodine deficiency during fetal development

The Journal of Nutrition
B S Hetzel, M T Mano

Abstract

Iodine deficiency is now recognized as a major international public health problem. It is estimated that 800 million people may be at risk of the effects of iodine deficiency. In humans, the effects occur at all stages of development: the fetus, the neonate, the child and adult. The effects are now denoted by the term iodine deficiency disorders (IDD). They include miscarriages, stillbirths, congenital anomalies, as well as the more familiar goiter, cretinism, impaired brain function, and hypothyroidism in children and adults. In domestic animals, reproductive failure has been reported with the production of aborted, stillborn and weak calves. Experimental studies in animal models have been reviewed to provide evidence of the mechanisms involved, particularly in relation to brain development. The findings in three different species (rat, sheep, monkey) indicate that the effects are mediated by a combination of maternal and fetal hypothyroidism, the effect of maternal hypothyroidism being earlier than the onset of fetal thyroid secretion. The findings suggest that iodine deficiency has an early effect on neuroblast multiplication and, if so, this could be important in the pathogenesis of the neurological form of endemic cretinis...Continue Reading

Citations

Oct 16, 2007·Applied and Environmental Microbiology·Seigo AmachiTakaaki Fujii
Mar 27, 2012·Applied and Environmental Microbiology·Mio SuzukiSeigo Amachi
Dec 29, 1994·The New England Journal of Medicine·B S Hetzel
Mar 18, 2000·The Journal of Nutrition·B S Hetzel
Apr 27, 2004·Indian Journal of Pediatrics·Vani Sethi, Umesh Kapil
Jan 1, 1990·Nutrition Research Reviews·J J Robinson
Jul 24, 2007·Applied and Environmental Microbiology·Seigo AmachiTakaaki Fujii
May 26, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Fatih KişlalTahsin Teziç
Mar 29, 2013·European Journal of Pain : EJP·I G N AlvesV J de Santana-Filho
Jan 1, 2011·Animal : an International Journal of Animal Bioscience·P MedicaA Ferlazzo
Dec 6, 2011·Microbial Ecology·Yumi ArakawaSeigo Amachi
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·A NuddaG Pulina
Dec 29, 2000·Thyroid : Official Journal of the American Thyroid Association·P LaurbergL Ovesen
Mar 11, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·J SackR Gutekunst
May 2, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christy S CarterWilliam E Sonntag
Jan 1, 1995·Journal of Endocrinological Investigation·F A Aghini LombardiM Marcheschi
May 29, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·J C Dillon, J Milliez
Jun 14, 2012·Integrative Zoology·Antoni V Milewski, Ellen S Dierenfeld
Dec 29, 1994·The New England Journal of Medicine·X Y CaoG R DeLong
Jul 1, 1996·The Medical Journal of Australia·B S Hetzel
Jun 1, 1995·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·S Maile
Jul 12, 2021·Journal of Health Economics·Daniel AraújoBreno Sampaio
Mar 15, 2003·Gastroenterology Clinics of North America·Elie Hamaoui, Michal Hamaoui
Apr 18, 1998·Gastroenterology Clinics of North America·E Hamaoui, M Hamaoui
Sep 26, 2006·Reproductive Toxicology·Xue F YangXiu F Sun
Dec 1, 2012·Environmental Science & Technology·Miharu SekiSeigo Amachi
Dec 7, 2021·The Journal of Dairy Research·Veronica CarnicelliAntonio Di Giulio

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