A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis

Frontiers in Cell and Developmental Biology
Angana MukherjeeJacqueline D Jones

Abstract

Development and cancer share a variety of functional traits such as EMT, cell migration, angiogenesis, and tissue remodeling. In addition, many cellular signaling pathways are noted to coordinate developmental processes and facilitate aspects of tumor progression. The Forkhead box superfamily of transcription factors consists of a highly conserved DNA binding domain, which binds to specific DNA sequences and play significant roles during adult tissue homoeostasis and embryogenesis including development, differentiation, metabolism, proliferation, apoptosis, migration, and invasion. Interestingly, various studies have implicated the role of key Fox family members such as FOXP, FOXO, and FOXA during cancer initiation and metastases. FOXI3, a member of the Forkhead family affects embryogenesis, development, and bone remodeling; however, no studies have reported a role in cancer. In this review, we summarize the role of FOXI3 in embryogenesis and bone development and discuss its potential involvement in cancer progression with a focus on the bone metastasis. Moreover, we hypothesize possible mechanisms underlying the role of FOXI3 in the development of solid tumor bone metastasis.

References

Jul 1, 1990·Molecular and Cellular Biology·T JacksonJ L Swain
Apr 30, 1998·Physiological Reviews·K Takahashi, Y Okamura
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Jun 13, 2003·Trends in Genetics : TIG·Ordan J LehmannShomi S Bhattacharya
Nov 2, 2004·Nature Reviews. Immunology·Paul J Coffer, Boudewijn M T Burgering
Jun 9, 2006·Acta Oncologica·Fergal C KelleherMairin Rafferty
Sep 25, 2007·Cell·Geetu Tuteja, Klaus H Kaestner
Oct 10, 2007·Cell·Geetu Tuteja, Klaus H Kaestner
Jun 10, 2008·Developmental Cell·Jing Yang, Robert A Weinberg
Sep 13, 2008·Science·Cord DrögemüllerTosso Leeb
Jan 11, 2012·Cell Research·Annita Achilleos, Paul A Trainor
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Dec 5, 2012·Cold Spring Harbor Perspectives in Biology·Jean B RegardYingzi Yang
Feb 19, 2013·Veterinary Dermatology·Dominique J WienerMonika M Welle
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·So NakagawaMartha L Bulyk
May 2, 2014·Developmental Biology·Safia B KhatriAndrew K Groves
Jun 18, 2014·Molecular and Cellular Biology·Daniel P HollernEran R Andrechek
Feb 7, 2015·American Journal of Medical Genetics. Part a·Elisa TassanoGiorgio Gimelli
Apr 9, 2015·Clinical and Translational Medicine·Sarah HeerbothSibaji Sarkar
Nov 7, 2015·Cell·UNKNOWN Cancer Genome Atlas Research Network
Mar 19, 2016·Stem Cells·Vera ShirokovaMarja L Mikkola
Nov 24, 2016·Cancer Metastasis Reviews·Christine L ChafferRobert A Weinberg
Feb 22, 2017·CA: a Cancer Journal for Clinicians·Mark K BuyyounouskiDaniel W Lin

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Datasets Mentioned

BETA
GSE65725
GSE68985
GSE74685

Software Mentioned

cBioPortal
RSEM

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