A review of guidance on immunization in persons with defective or deficient splenic function

British Journal of Haematology
Ernest KucharMonika Karlikowska

Abstract

The spleen acts as a blood filter and lymphopoietic organ. Asplenic and hyposplenic individuals are more susceptible to serious infections caused by encapsulated bacteria but they can be protected by antibiotic prophylaxis and immunizations. Recent progress in vaccinology means prophylaxis is now successful in the vast majority of serious infections with pneumococci, meningococci and Haemophilus influenzae type b responsible for the majority of cases of overwhelming sepsis in asplenic patients. Current guidelines are coherent. Physicians treating patients with conditions associated with hyposplenism are ethically obliged to immunize their patients using the vaccines currently available to protect them from largely preventable, life-threatening infections.

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Citations

Jan 12, 2016·Human Vaccines & Immunotherapeutics·Giuseppe MurdacaFilippo Ansaldi
Mar 19, 2016·Blood·Luca ArcainiMarco Paulli
May 31, 2016·American Journal of Hematology·Emmanuel BalandyaJulie Makani
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Aug 12, 2017·Internal and Emergency Medicine·Antonio Di SabatinoGino Roberto Corazza
Jun 10, 2021·Medicina clínica·Lourdes MateoUNKNOWN en representación del Comité de infecciones en paciente tratados con inmunosupresores selectivos del Hospital Germans Trias

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