PMID: 6403218Apr 1, 1983Paper

A review of hereditary malignant melanoma including biomarkers in familial atypical multiple mole melanoma syndrome

Cancer Genetics and Cytogenetics
H T LynchJ F Lynch

Abstract

This review provides a comprehensive coverage of hereditary malignant melanoma with emphasis upon its heterogeneity as well as newly developed biomarker investigations. The recently described familial atypical multiple mole melanoma (FAMMM) syndrome is featured. Particular attention has been given to findings of increased hyperdiploidy observed as an in vitro phenomenon in cultured skin fibroblasts from high-risk and FAMMM-affected subjects. The FAMMM genotype is complex in that it predisposes a patient not only to melanoma (cutaneous and intraocular malignant melanoma) but also to other histologic varieties of cancer, including cancer of the lung, pancreas, and breast. Attention is given to cancer surveillance and management programs for patients at increased risk for the several forms of hereditary malignant melanoma. This approach capitalizes advantageously upon employment of a knowledge of genetics and hereditary cancer syndrome identification, with particular attention to tumor associations.

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Citations

Jun 1, 1991·Cancer Metastasis Reviews·J M Trent
Sep 1, 1984·Cancer Genetics and Cytogenetics·H T LynchB S Danes
Feb 15, 1986·Cancer Genetics and Cytogenetics·H T Lynch, R M Fusaro
Oct 1, 1988·Cancer Genetics and Cytogenetics·F Hecht, B K Hecht
Feb 1, 1990·The Journal of Dermatologic Surgery and Oncology·R K Roenigk, H H Roenigk
Oct 19, 2012·Biomarkers in Medicine·Sukhwinder KaurSurinder K Batra
Mar 1, 1995·Journal of the American Academy of Dermatology·J SladeR S Bart
Jun 1, 1994·The Journal of Pediatrics·M L Williams, R Pennella
Jan 1, 1985·Annals of the New York Academy of Sciences·M A Pathak
Nov 1, 1993·Cancer Genetics and Cytogenetics·H T LynchM Leppert
Oct 1, 1983·Journal of Medical Genetics·H T LynchB S Danes
Feb 1, 1984·Cancer·H T LynchC A Wagner
Dec 15, 1984·International Journal of Cancer. Journal International Du Cancer·G Mueller-EckhardtC Mueller-Eckhardt
Aug 8, 2021·International Journal of Environmental Research and Public Health·Oriana D'EcclesiisSusanna Chiocca

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