PMID: 2510249Jan 1, 1989Paper

A review of mucosal protection by synthetic prostaglandin E analogs against injury by non-steroidal anti-inflammatory agents

Scandinavian Journal of Gastroenterology. Supplement
F L Lanza

Abstract

Non-steroidal anti-inflammatory agents (NSAIDs) damage the gastric mucosa both in normal volunteers and in arthritic patients. Four large studies have been done in our laboratory comparing the prostaglandin E analog misoprostol against placebo, cimetidine, and sucralfate. These studies showed that misoprostol protected the stomach significantly better than cimetidine or sucralfate. In the duodenum, misoprostol and cimetidine were equally effective. Comparison of secretory and anti-secretory doses of misoprostol reveal duodenal protection with the former but not with the latter, but gastric protection with both doses, suggesting that cytoprotective mechanisms other than acid suppression exist in the stomach in subjects taking prostaglandins. Adequately controlled and blind studies reported in the literature in arthritic patients are also reviewed, and it would appear that prostaglandins offer the best currently available method of providing mucosal protection for patients taking NSAIDs.

References

Mar 1, 1986·Lancet·K SomervilleM Langman
Feb 1, 1986·Digestive Diseases and Sciences·F E SilversteinD S Levine
Jun 1, 1987·Scandinavian Journal of Gastroenterology·A Malchow-Møller, P J Ranløv
Jan 1, 1985·British Journal of Clinical Pharmacology·J K RamageJ G Williams

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Citations

Jul 1, 1995·The Annals of Pharmacotherapy·C L Crinnion, G M McCart
Sep 1, 1993·Scandinavian Journal of Gastroenterology·J W KonturekW Domschke
Jun 1, 1996·Journal of Clinical Gastroenterology·J StachuraW Domschke
Oct 1, 1993·Alimentary Pharmacology & Therapeutics·N HudsonC J Hawkey
Jun 1, 1995·Journal of Gastroenterology·J StachuraW Domschke
Mar 20, 1998·AORN Journal·M A Fiedler, C Biddle
Dec 1, 1993·Scandinavian Journal of Gastroenterology·S J KonturekJ Oleksy
Aug 9, 2006·European Journal of Gastroenterology & Hepatology·Massimo MontaltoGiovanni Gasbarrini
Dec 1, 1994·Postgraduate Medicine·Russell I Heigh

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