A review of negative symptom assessment strategies in youth at clinical high-risk for psychosis.

Schizophrenia Research
Gregory P StraussVijay A Mittal

Abstract

Studies attempting to deconstruct the heterogeneity of schizophrenia and the attenuated psychosis syndrome consistently find that negative symptoms are a core dimension that is distinct from other aspects of the illness (e.g., positive and disorganized symptoms). Negative symptoms are also highly predictive of poor community-based functional outcomes, suggesting they are a critical treatment target. Unfortunately, pharmacological and psychosocial treatments for negative symptoms have demonstrated limited effectiveness. To address this critical unmet therapeutic need, the NIMH sponsored a consensus development conference to delineate research priorities for the field and stimulate treatment development. A primary conclusion of this meeting was that next-generation negative symptom rating scales should be developed to address methodological and conceptual limitations of existing instruments. Although second-generation rating scales were developed for adults with schizophrenia, progress in this area has lagged behind for youth at clinical-high risk (CHR) for developing psychosis (i.e. those meeting criteria for a prodromal syndrome). Given that negative symptoms are highly predictive of the transition to diagnosable psychotic illn...Continue Reading

Citations

May 18, 2020·Schizophrenia Research·Scott W WoodsAlbert R Powers
Jul 27, 2021·Journal of Psychiatry and Brain Science·Vijay A MittalJames M Gold
Jul 10, 2021·Schizophrenia Bulletin·LeeAnn Akouri-ShanJames A Waltz
Aug 7, 2021·Schizophrenia Research·Jessica R Lunsford-AveryVijay A Mittal
Aug 6, 2021·Behavioural Brain Research·Gary RemingtonOfer Agid
Aug 25, 2021·Early Intervention in Psychiatry·David J MiklowitzCarrie E Bearden
Nov 3, 2021·Early Intervention in Psychiatry·Jordyn R RicardVijay A Mittal

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