Abstract
Hypertension is the most commonly encountered medical condition in pregnancy, contributing significantly to maternal and perinatal morbidity and mortality. Mild to moderate hypertension in pregnancy is defined as systolic blood pressure of 140-159 mmHg or diastolic blood pressure of 90-109 mmHg (7-9% of pregnancies). When treating hypertension in pregnancy, not only do physiologic changes of pregnancy have an effect on the pharmacokinetics and pharmacodynamics of the drugs used, but the pathophysiology of hypertensive disorders of pregnancy also have an effect. To date, evidence is lacking on the pharmacokinetics and pharmacodynamics of commonly used antihypertensive drugs, which often times leads to suboptimal treatment of hypertensive pregnant women. When considering which agents to use for treatment of mild to moderate hypertension, specifically in gestational and chronic hypertension, oral labetalol and nifedipine are valid options. An overview of the profile for use, safety, and current pharmacokinetic data for each agent is presented here.
References
Aug 1, 1991·Clinical Pharmacokinetics·R Donnelly, G J Macphee
Feb 1, 1990·American Journal of Obstetrics and Gynecology·R C RogersW D Whybrew
Sep 1, 1985·Drugs·E M SorkinR N Brogden
Apr 1, 1983·Journal of Clinical Pharmacology·T S FosterR G McAllister
Oct 1, 1993·Journal of Clinical Pharmacology·T SaotomeT Ishizaki
May 23, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·L A Magee
Oct 29, 2004·Clinical Pharmacokinetics·Vassilis TsatsarisBruno Carbonne
Jul 16, 2005·American Journal of Obstetrics and Gynecology·Laura A MageePeter von Dadelszen
Aug 2, 2007·American Journal of Therapeutics·Dimitri N M PapatsonisGuus A Dekker
May 10, 2008·Cardiovascular Therapeutics·Firas A Ghanem, Assad Movahed
Feb 26, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Khalid KhanBryan Beattie
May 7, 2011·British Journal of Clinical Pharmacology·Laura A MageeUNKNOWN CHIPS Study Group
Jan 18, 2012·Archives of Gynecology and Obstetrics·Shaba N MolviA Rauoof Malik
May 15, 2012·Archives of Gynecology and Obstetrics·Stefano R GiannubiloAndrea L Tranquilli
Sep 12, 2012·Hypertension·Brian T BatemanMichael A Fischer
Nov 3, 2012·Archives of Disease in Childhood. Fetal and Neonatal Edition·Nikolaos DaskasJulian P H Shield
Jun 12, 2013·Hypertension·Mohammad Y YakoobRebecca A Hoban
Sep 12, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·B T BatemanM A Fischer
Oct 22, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ri-hua XieShi Wu Wen
Dec 4, 2013·Clinical Pharmacokinetics·James H FischerKeith A Rodvold
Jan 5, 2014·Journal of Hypertension·Khalid A J Al KhajaAwatif H H Damanhori
Feb 8, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ri-hua XieShi Wu Wen
Citations
Oct 28, 2016·Journal of Clinical Pharmacy and Therapeutics·D-D ShiN Wang
Oct 1, 2016·Expert Opinion on Drug Safety·Farah H AmroBaha M Sibai
Jul 21, 2017·Journal of Clinical Pharmacy and Therapeutics·D-D ShiN Wang
Dec 12, 2017·Frontiers in Pharmacology·Dan-Dan ShiNa Wang
Feb 3, 2018·Medicine·Kelvin Kl NgAlex Polyakov
Apr 28, 2018·Physiological Genomics·Katherine J PerschbacherJustin L Grobe
Jul 3, 2019·Experimental Biology and Medicine·Mei Zhang, Huanrong Feng
Aug 31, 2018·European Heart Journal·Vera Regitz-ZagrosekUNKNOWN ESC Scientific Document Group
Apr 14, 2016·Current Hypertension Reports·Giorgina Barbara PiccoliTullia Todros
Jan 27, 2019·Medicine·Kelvin Kwok Lap NgAlex Polyakov
Jun 4, 2020·Arquivos brasileiros de cardiologia·Walkiria Samuel AvilaTatiana de Carvalho Andreuci Torres Leal
May 28, 2019·AAPS PharmSciTech·Megha N Karemore, Jasmine G Avari
Feb 27, 2021·Hipertensión y riesgo vascular·A M GhelfiG J Staffieri
May 18, 2021·Frontiers in Pharmacology·Raju KhatriCraig R Lee
Nov 6, 2021·Expert Opinion on Drug Metabolism & Toxicology·Ian R MulreninCraig R Lee