A Review of Podocyte Biology

American Journal of Nephrology
Puneet Garg

Abstract

Podocyte biology is a developing science that promises to help improve understanding of the mechanistic nature of multiple diseases associated with proteinuria. Proteinuria in nephrotic syndrome has been linked to mechanistic dysfunctions in the renal glomerulus involving the function of podocyte epithelial cells, including podocyte foot process effacement. Developments in imaging technology are improving knowledge of the detailed structure of the human renal glomerulus and cortex. Podocyte foot processes attach themselves to the glomerular capillaries at the glomerular basement membrane (GBM) forming intercellular junctions that form slit diaphragm filtration barriers that help maintain normal renal function. Damage in this area has been implicated in glomerular disease. Injured podocytes undergo effacement whereby they lose their structure and spread out, leading to a reduction in filtration barrier function. Effacement is typically associated with the presence of proteinuria in focal segmental glomerulosclerosis, minimal change disease, and diabetes. It is thought to be due to a breakdown in the actin cytoskeleton of the foot processes, complex contractile apparatuses that allow podocytes to dynamically reorganize according ...Continue Reading

Citations

Oct 27, 2018·Histochemistry and Cell Biology·Ramona Jühlen, Birthe Fahrenkrog
Jan 31, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hernán Trimarchi, Rosanna Coppo
May 30, 2019·The Biochemical Journal·Yanyan GuoXiaoqiang Guo
Jul 23, 2019·Cancer Biology & Therapy·Hiroyuki TerasawaHiroyuki Okada
Jan 24, 2020·Fetal and Pediatric Pathology·Tyrus StewartDiego Aviles
Jan 7, 2020·American Journal of Physiology. Renal Physiology·Brian R StotterJohannes S Schlondorff
Jun 6, 2020·Clinical Science·Paul A Reynolds
Sep 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thaddäus StrukHermann Pavenstädt
Jan 27, 2019·Journal of Cellular Physiology·Olivier DelézayXavier Delavenne
Jul 28, 2020·Cells·Judith Blaine, James Dylewski
Jul 15, 2020·Scientific Reports·Joichi UsuiKunihiro Yamagata
Sep 29, 2020·Frontiers in Physiology·Larissa de AraújoMaria Oliveira-Souza
Nov 15, 2019·F1000Research·Moin A Saleem, Gavin I Welsh
Jul 19, 2019·Arkhiv patologii·V G SipovskyA V Smirnov
Dec 15, 2020·American Journal of Physiology. Renal Physiology·Wenjun GaoFan Fan
Dec 29, 2020·Frontiers in Pharmacology·Swayam Prakash SrivastavaJulie E Goodwin
Jan 15, 2021·Journal of the American Society of Nephrology : JASN·Hua SunMartin R Pollak
Feb 24, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Takahiro IshikawaKoutaro Yokote
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi-Qi YangPeng Xu
Feb 26, 2021·Journal of Toxicologic Pathology·Naoaki YamadaYoshiyasu Kobayashi
Mar 11, 2021·Journal of the American Society of Nephrology : JASN·Annika Möller-KeruttThomas Weide
Mar 20, 2021·Journal of Cellular Physiology·Tomasz Kulesza, Agnieszka Piwkowska
Apr 1, 2021·Journal of the American Society of Nephrology : JASN·Marlies SachsCatherine Meyer-Schwesinger
Apr 17, 2021·Life Sciences·Rahim IranzadMehdi Yousefi
May 1, 2021·International Journal of Molecular Sciences·Kana Asano-MatsudaJun Matsuda
Aug 5, 2020·Molecular and Cellular Endocrinology·Robert Jp PopeCraig A McArdle
Jul 3, 2021·Cells·Tjessa BondueMohamed A Elmonem
Jul 11, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maurizio Salvadori, Aris Tsalouchos
Aug 1, 2021·Journal of the American Society of Nephrology : JASN·Haijiao ZhangRongguang Zhang
Sep 21, 2021·Tissue Engineering. Part B, Reviews·Sarah WilliamsBalajikarthick Subramanian
Sep 26, 2021·Scientific Reports·Mariana Charleaux de PonteMaria Oliveira-Souza
Oct 9, 2021·CEN Case Reports·Ryunosuke NodaYoshitaka Ishibashi
Oct 20, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lingfeng Zeng, Cheuk-Chun Szeto
Oct 31, 2021·Journal of the American Society of Nephrology : JASN·Stuart J ShanklandOliver Wessely
Jan 4, 2022·International Urology and Nephrology·Andrew Y XiaoPing L Zhang

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