A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures

International Journal of Radiation Biology
Vijay K Singh, Thomas M Seed

Abstract

The increasing global risk of nuclear and radiological accidents or attacks has driven renewed research interest in developing medical countermeasures to potentially injurious exposures to acute irradiation. Clinical symptoms and signs of a developing acute radiation injury, i.e. the acute radiation syndrome, are grouped into three sub-syndromes named after the dominant organ system affected, namely the hematopoietic, gastrointestinal, and neurovascular systems. The availability of safe and effective countermeasures against the above threats currently represents a significant unmet medical need. This is the first article within a three-part series covering the nature of the radiation sub-syndromes, various animal models for radiation countermeasure development, and the agents currently approved by the United States Food and Drug Administration for countering the medical consequences of several of these prominent radiation exposure-associated syndromes. From the U.S. and global perspectives, biomedical research concerning medical countermeasure development is quite robust, largely due to increased government funding following the 9/11 incidence and subsequent rise of terrorist-associated threats. A wide spectrum of radiation cou...Continue Reading

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Citations

Jun 14, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fariborz SoroushMohammad F Kiani
Dec 19, 2018·International Journal of Radiation Biology·Laura E EwingIgor Koturbash
Mar 2, 2019·International Journal of Radiation Biology·Angela M Groves, Jacqueline P Williams
Apr 23, 2019·Expert Opinion on Drug Discovery·Vijay K SinghAyodele O Olabisi
Apr 26, 2019·International Journal of Radiation Biology·Deborah I BuninPolly Y Chang
Sep 19, 2019·Expert Opinion on Drug Safety·Vijay K Singh, Thomas M Seed
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Jan 29, 2020·Nature Biomedical Engineering·David B ChouDonald E Ingber
Feb 11, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mayuri BandekarSantosh K Sandur
Mar 16, 2019·International Journal of Molecular Sciences·Amrita K CheemaVijay K Singh
Oct 3, 2018·Expert Opinion on Drug Discovery·Vijay K SinghThomas J MacVittie
Oct 6, 2020·Oxidative Medicine and Cellular Longevity·Patrick C BradshawWilliam M Curtis
Jun 9, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Min WangXiaobo Sun
Feb 6, 2020·Scientific Reports·Merriline SatyamitraSanchita P Ghosh
Oct 17, 2020·Drug Discovery Today·Vijay K Singh, Thomas M Seed
Nov 5, 2020·Biomedicines·Elena ObradorAlegría Montoro
Feb 14, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Harshani WijerathneMohammad F Kiani
Aug 26, 2019·Critical Care Clinics·John S Parrish, Gilbert Seda
Mar 20, 2021·Scientific Reports·Yaoxiang LiVijay K Singh
Jun 5, 2021·Mutagenesis·Teena HaritwalPaban K Agrawala

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