A Review of Radiotherapy-Induced Late Effects Research after Advanced Technology Treatments

Frontiers in Oncology
Wayne D NewhauserChoonsik Lee

Abstract

The number of incident cancers and long-term cancer survivors is expected to increase substantially for at least a decade. Advanced technology radiotherapies, e.g., using beams of protons and photons, offer dosimetric advantages that theoretically yield better outcomes. In general, evidence from controlled clinical trials and epidemiology studies are lacking. To conduct these studies, new research methods and infrastructure will be needed. In the paper, we review several key research methods of relevance to late effects after advanced technology proton-beam and photon-beam radiotherapies. In particular, we focus on the determination of exposures to therapeutic and stray radiation and related uncertainties, with discussion of recent advances in exposure calculation methods, uncertainties, in silico studies, computing infrastructure, electronic medical records, and risk visualization. We identify six key areas of methodology and infrastructure that will be needed to conduct future outcome studies of radiation late effects.

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Nov 28, 2017·Radiation Protection Dosimetry·W D NewhauserW Donahue
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Dec 31, 2021·Physics in Medicine and Biology·Erika KollitzKatia Parodi

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Methods Mentioned

BETA
X-ray
irradiating
surgical resection

Software Mentioned

MCNP
DOSExyz
GEANT4
MCDOSE
FLUKA
Electron Gamma Shower ( EGS ) code

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