A review of spatial computational models for multi-cellular systems, with regard to intestinal crypts and colorectal cancer development.

Journal of Mathematical Biology
Giovanni De MatteisMarco Antoniotti

Abstract

Colon rectal cancers (CRC) are the result of sequences of mutations which lead the intestinal tissue to develop in a carcinoma following a "progression" of observable phenotypes. The actual modeling and simulation of the key biological structures involved in this process is of interest to biologists and physicians and, at the same time, it poses significant challenges from the mathematics and computer science viewpoints. In this report we give an overview of some mathematical models for cell sorting (a basic phenomenon that underlies several dynamical processes in an organism), intestinal crypt dynamics and related problems and open questions. In particular, major attention is devoted to the survey of so-called in-lattice (or grid) models and off-lattice (off-grid) models. The current work is the groundwork for future research on semi-automated hypotheses formation and testing about the behavior of the various actors taking part in the adenoma-carcinoma progression, from regulatory processes to cell-cell signaling pathways.

References

Sep 1, 1978·The Journal of Cell Biology·W R Springer, S H Barondes
May 1, 1992·Developmental Biology·U Technau, T W Holstein
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F Siegert, C J Weijer
Jul 23, 1990·Proceedings. Biological Sciences·D J Winton, B A Ponder
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jan 1, 1989·Critical Reviews in Biochemistry and Molecular Biology·P B Armstrong
Jan 1, 1988·Journal of Cell Science. Supplement·C S Potten, R J Morris
Jul 1, 1988·Cell and Tissue Kinetics·C S PottenU Paulus
Jan 1, 1987·Annual Review of Cell Biology·D R McClay, C A Ettensohn
Nov 1, 1986·Cell and Tissue Kinetics·P Kaur, C S Potten
Sep 27, 1972·Nature: New Biology·A GiererE Trenkner
Dec 1, 1972·The Journal of Cell Biology·P B Armstrong, D Parenti
Mar 1, 1969·Journal of Theoretical Biology·S A Kauffman
Feb 7, 1984·Journal of Theoretical Biology·D SulskyJ K Percus
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H G Othmer, E Pate
Jan 1, 1981·Journal of Cellular Physiology·J LandryR M Sutherland
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·S MunemitsuP Polakis
May 7, 1993·Science·S N ThibodeauD Schaid
Feb 21, 1996·Journal of Theoretical Biology·M Bjerknes
Aug 1, 1996·Journal of Bioenergetics and Biomembranes·D W Laird
Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
May 30, 1997·Science·C S ChenD E Ingber
Jun 1, 1997·Journal of Neuropathology and Experimental Neurology·P K BurgessE C Alvord
May 30, 1997·Science·E Ruoslahti
Aug 1, 1997·International Journal of Experimental Pathology·C S PottenD M Pritchard
Jan 19, 1999·Annual Review of Cell and Developmental Biology·A Wodarz, R Nusse
Feb 3, 1999·Annals of the New York Academy of Sciences·M Höcker, B Wiedenmann
Mar 1, 1993·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J A Glazier, F Graner
Jul 1, 1993·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J C MombachJ R Iglesias

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Citations

Feb 6, 2016·BMC Bioinformatics·Andrea ParoniMarco Antoniotti
Dec 21, 2013·International Journal of Experimental Pathology·Kieran Smallbone, Bernard M Corfe
Jan 19, 2016·Mathematical Biosciences and Engineering : MBE·Oliver J MaclarenPhilip K Maini
May 23, 2014·Biochemical Society Transactions·Peter BuskeJoerg Galle
Oct 17, 2013·Mathematical Biosciences·M R NelsonO E Jensen
Oct 15, 2013·Progress in Biophysics and Molecular Biology·Alexander G FletcherDavid J Gavaghan
Aug 19, 2016·Journal of the Royal Society, Interface·Torsten ThalheimJoerg Galle
Jul 3, 2013·Briefings in Functional Genomics·Michal-Ruth SchweigerBernd Timmermann
Feb 14, 2017·PLoS Computational Biology·James M OsborneDavid J Gavaghan
Jul 20, 2016·PLoS Computational Biology·Zheng SunNatalia L Komarova
Jul 29, 2017·PLoS Computational Biology·Oliver J MaclarenPhilip K Maini
Oct 16, 2015·Cancer Informatics·James M Osborne
Feb 1, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Alexis J CarulliSantiago Schnell
Jan 31, 2018·Physical Biology·A J FendrikE Rotondo
Apr 3, 2020·Medical & Biological Engineering & Computing·Zahra Sadat Hosseini, Seyed Mohammad Reza Hashemi Golpayegani
Sep 19, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Tibor AntalM A Nowak

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