A review of SSRIs and SNRIs in neuropathic pain

Expert Opinion on Pharmacotherapy
Yee-Chi Lee, Phoon-Ping Chen

Abstract

Selective serotonin reuptake inhibitors (SSRIs) and serotonin noradrenaline reuptake inhibitors (SNRIs) are becoming increasingly used in the treatment of neuropathic pain and fibromyalgia. However, they are not without adverse effects and their efficacy has not been clear because of conflicting evidence. We have examined the current evidence on the efficacy of SSRIs and SNRIs in the treatment of neuropathic pain and fibromyalgia. Relevant randomized, placebo-controlled studies were identified through a MEDLINE search of English-language literature from January 1990 to December 2009. The evidence for efficacy of SSRIs in the treatment neuropathic pain is moderate at best. However, SNRIs, venlafaxine and duloxetine have been shown to be effective in the treatment of painful diabetic neuropathy and polyneuropathy. With fibromyalgia, both SSRIs (fluoxetine and paroxetine) and SNRIs (duloxetine and milnacipran) have been shown to improve pain relief, function and quality of life. SSRIs and SNRIs may be considered in the treatment of neuropathic pain if treatment with tricyclic antidepressants and anticonvulsants fails, or if there are contraindications to these drugs. There is also sufficient evidence to indicate that SNRIs are eff...Continue Reading

References

Jan 1, 1978·Annual Review of Physiology·H L Fields, A I Basbaum
Nov 1, 1992·Clinical Pharmacology and Therapeutics·S H SindrupL F Gram
May 7, 1992·The New England Journal of Medicine·M B MaxR Dubner
Jan 1, 1991·Annual Review of Neuroscience·H L FieldsP Mason
Jan 1, 1984·Annual Review of Neuroscience·A I Basbaum, H L Fields
Jun 1, 1995·Pain·J NørregaardB Danneskiold-Samsøe
Jan 1, 1994·Scandinavian Journal of Rheumatology·F WolfeD J Hawley
Mar 1, 1993·Clinical Pharmacokinetics·J van Harten
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Sep 1, 1996·International Clinical Psychopharmacology·C Puozzo, B E Leonard
Mar 1, 1997·Journal of Clinical Epidemiology·P CherinD Sereni
Dec 16, 1997·The American Journal of Psychiatry·M FavaJ F Rosenbaum
Apr 29, 1998·Harvard Review of Psychiatry·A C VigueraJ Friedberg
Sep 30, 1998·The European Journal of Neuroscience·J J AzkueT Herdegen
Jun 17, 1999·Lancet·C J Woolf, R J Mannion
Jun 22, 1999·Current Biology : CB·A I Basbaum, C J Woolf
Jun 2, 2000·European Journal of Pain : EJP·U M AnderbergL von Knorring
Jun 10, 2000·Science·C J Woolf, M W Salter
Mar 13, 2002·European Journal of Pain : EJP·Tiina TasmuthEija Kalso
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jun 28, 2002·Trends in Neurosciences·Frank PorrecaG F Gebhart
Oct 31, 2002·Nature Neuroscience·Joachim Scholz, Clifford J Woolf
May 17, 2003·Pain·Yukari SudohGing Kuo Wang
Jul 2, 2003·American Journal of Epidemiology·Richard HubbardAnne Tattersfield
Aug 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·R J LantzM P Knadler
Mar 6, 2004·Clinical Pharmacology and Therapeutics·Wayne A RayKatherine T Murray
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·D A FishbainR S Rosomoff
May 25, 2005·Basic & Clinical Pharmacology & Toxicology·Søren H SindrupTroels S Jensen
Jun 2, 2005·Pain·David J GoldsteinSmriti Iyengar
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joachim ScholzClifford J Woolf

❮ Previous
Next ❯

Citations

Nov 28, 2012·Pharmacology·Krystyna Cegielska-PerunHelena Elżbieta Makulska-Nowak
Aug 15, 2014·Science Translational Medicine·David BorsookFrank Porreca
Mar 14, 2014·Expert Opinion on Drug Metabolism & Toxicology·Barbara GardellaArsenio Spinillo
Aug 30, 2014·Expert Opinion on Investigational Drugs·Ernest AdeghateHuba Kalász
Aug 14, 2013·Molecular Pain·Stéphanie Grégoire, Volker Neugebauer
Dec 7, 2013·Gastroenterología y hepatología·Antonio Ojeda, Luis A Moreno
Jan 23, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Madhu SangaAravind Mittur
Oct 9, 2012·International Journal of Oral and Maxillofacial Surgery·W J J M MartinT Forouzanfar
Mar 2, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jian YuAravind Mittur
Jan 12, 2011·The British Journal of Dermatology·H L Tey, G Yosipovitch
Jul 19, 2015·European Journal of Pharmacology·Olivier ThériaultMohamed Chahine
Apr 5, 2016·Dental Clinics of North America·Leslie Halpern, Porchia Willis
Apr 23, 2013·Pharmacology, Biochemistry, and Behavior·Shinichi OginoHiroyuki Ito
Jan 7, 2015·Pharmacological Reports : PR·Krystyna Cegielska-PerunMagdalena Bujalska-Zadrożny
Dec 6, 2016·Female Pelvic Medicine & Reconstructive Surgery·Marsha K GuessArnold Melman
Jan 6, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Jeremy M Thompson, Volker Neugebauer
Aug 25, 2015·The Cochrane Database of Systematic Reviews·Helen C GallagherMartin C Henman
Sep 21, 2013·Nature Reviews. Rheumatology·Anne-Marie Malfait, Thomas J Schnitzer
Sep 15, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alexander LisinskiElias Eriksson
Jan 22, 2015·Clinical Obstetrics and Gynecology·Libby Edwards
Mar 28, 2020·Journal of the American Geriatrics Society·Russell K Portenoy
Jun 25, 2017·Heart Failure Reviews·Diana Stewart, Mary Lynn McPherson
Aug 12, 2017·Psychopharmacology·Sarah L MartinAnthony K P Jones
Apr 17, 2019·International Journal of Molecular Sciences·Daxian LiWoojin Kim
Jul 25, 2020·Current Pain and Headache Reports·Mariam Salisu OrhurhuVwaire Orhurhu
Feb 6, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Abbas AlimoradianJamal Amri
Jul 22, 2021·Current Cancer Drug Targets·Diala MerhebHazem I Assi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
N AttalT Nurmikko
Trends in Pharmacological Sciences
Juan A MicóAlain Eschalier
© 2021 Meta ULC. All rights reserved