PMID: 11604074Oct 18, 2001Paper

A review of studies of ionizing radiation-induced double-strand break clustering

Radiation Research
K M PriseB D Michael

Abstract

Underpinning current models of the mechanisms of the action of radiation is a central role for DNA damage and in particular double-strand breaks (DSBs). For radiations of different LET, there is a need to know the exact yields and distributions of DSBs in human cells. Most measurements of DSB yields within cells now rely on pulsed-field gel electrophoresis as the technique of choice. Previous measurements of DSB yields have suggested that the yields are remarkably similar for different types of radiation with RBE values < or = 1.0. More recent studies in mammalian cells, however, have suggested that both the yield and the spatial distribution of DSBs are influenced by radiation quality. RBE values for DSBs induced by high-LET radiations are greater than 1.0, and the distributions are nonrandom. Underlying this is the interaction of particle tracks with the higher-order chromosomal structures within cell nuclei. Further studies are needed to relate nonrandom distributions of DSBs to their rejoining kinetics. At the molecular level, we need to determine the involvement of clustering of damaged bases with strand breakage, and the relationship between higher-order clustering over sizes of kilobase pairs and above to localized clust...Continue Reading

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Citations

Feb 4, 2014·The International Journal of Biochemistry & Cell Biology·Christophe Lavelle, Nicolas Foray
Jul 10, 2010·Radiation and Environmental Biophysics·Marcela Maria Pereira de Lemos PintoAdemir Amaral
May 29, 2012·Radiation and Environmental Biophysics·Jing Chen
Nov 30, 2010·Radiation Protection Dosimetry·K M Prise, G Schettino
Aug 7, 2012·Journal of Mathematical Biology·Yasumasa Saisho, Atsushi Ito
Oct 29, 2013·Vascular Cell·Peter Grabham, Preety Sharma
Sep 9, 2004·Radiation Protection Dosimetry·C K Wang, X Zhang
Nov 7, 2002·International Journal of Radiation Oncology, Biology, Physics·Peter C BrooksSilvia C Formenti
Sep 4, 2008·Radiation Research·Mary K WhalenJanice M Pluth
Jun 24, 2010·International Journal of Radiation Biology·Thomas E SchmidBarbara Röper
Apr 22, 2009·International Journal of Radiation Biology·Kathryn D Held
Dec 7, 2006·International Journal of Radiation Biology·Jonathan LoreeOlga Kovalchuk
Jul 27, 2007·International Journal of Radiation Biology·N UsamiC Le Sech
Jun 19, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Jorge Serment-GuerreroMiguel Balcázar
Jul 29, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kristell BastideSylvie Chevillard
Oct 31, 2012·Scientific Reports·Xin ZhouHong Zhang
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Feb 28, 2008·Radiation Research·Robert R KimmelJeffrey L Schwartz
Aug 8, 2014·Radiation Research·Janapriya SahaFrancis A Cucinotta

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