A review of sudden unexpected death in epilepsy: prediction of patients at risk

Epilepsy & Behavior : E&B
John R Hughes

Abstract

This review attempts to provide up-to-date quantitative data from published reports on sudden unexpected death in epilepsy (SUDEP) appearing on Medline and, especially, to provide a means to predict the probability of SUDEP in a given patient. The mean incidence of SUDEP was 1.8/1000, similar to the median of 1.5. The mean standardized mortality ratio was 6.8, and the mean percentage of SUDEP cases among deaths from epilepsy was 16.6. Seventeen risk factors were identified, each given a value according to the number of studies in the literature that specified that condition as a significant risk. The addition of these 17 values then indicated the risk for a given patient. The author calculated these for a group of 91 patients who died of SUDEP and also for 91 live patients. Many of their values for the different risks were significantly different. The sensitivity of these SUDEP values was 71.3%, the specificity 81.8%, and the positive predictive value 84.6%. A discussion includes the question of whether the death in SUDEP is primarily cardiac or pulmonary and the suggestion that it may be either or both in a given patient. The most important risk factor in this study was noncompliance with antiepileptic medication, and the main...Continue Reading

References

Jun 11, 1975·Neurology·C F TerrenceJ A Perper
Apr 1, 1991·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·R M Dasheiff
Jun 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·S J Howell, L D Blumhardt
Aug 1, 1989·Annals of Neurology·J E LeestmaS S Teas
Sep 1, 1987·Acta Neurologica Scandinavica·K LühdorfA M Plesner
Sep 1, 1985·The American Journal of Forensic Medicine and Pathology·J E LeestmaM B Kalelkar
Feb 1, 1986·Archives of Neurology·R M Dasheiff, L J Dickinson
Oct 1, 1985·Acta Neurologica Scandinavica·A Lund, H Gormsen
Apr 1, 1984·Forensic Science International : Synergy·T Särkioja, J Hirvonen
May 1, 1981·Annals of Neurology·C F TerrenceJ A Perper
Apr 1, 1995·Annals of Neurology·S C JohnstonR P Simon
Apr 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·L NashefS D Shorvon
Dec 1, 1993·Seizure : the Journal of the British Epilepsy Association·P L Timmings
Feb 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·P KlenermanS D Shorvon
Mar 1, 1996·Seizure : the Journal of the British Epilepsy Association·S J TavernorC Gifford
Jul 15, 1998·Seizure : the Journal of the British Epilepsy Association·G KennebäckL Bergfeldt
Sep 11, 1998·Seizure : the Journal of the British Epilepsy Association·P L Timmings
Oct 24, 1998·The American Journal of Emergency Medicine·C Smith-Demps, A Jagoda
Nov 10, 1998·Seizure : the Journal of the British Epilepsy Association·Y LanganM Hutchinson
Sep 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·R Kloster, T Engelskjøn
Oct 8, 1999·Seizure : the Journal of the British Epilepsy Association·J F Annegers, S P Coan
Oct 9, 1999·Epilepsy Research·M ThomF Scaravilli
Oct 16, 1999·Neurology·M J HennessyL Nashef
Jun 1, 2000·Archives of Disease in Childhood·B MorentinM P Suarez-Mier
Jun 10, 2000·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·K OpeskinS F Berkovic
Jul 8, 2000·Epilepsia·D M Ficker
Aug 10, 2000·American Journal of Mental Retardation : AJMR·J R McKee, J W Bodfish
Apr 12, 2001·Arquivos de neuro-psiquiatria·S A AntoniukJ L Castellano
Aug 8, 2001·Seizure : the Journal of the British Epilepsy Association·V VenkataramanH Motookal
Oct 31, 2001·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·T F YangT B Kuo
Feb 8, 2002·Journal of Clinical Pharmacology·Claire M Lathers, Paul L Schraeder
Apr 19, 2002·Brain : a Journal of Neurology·M J HilzM Dütsch
Sep 13, 2002·Acta Neurologica Scandinavica·S TigaranM Dam
Oct 26, 2002·Epilepsy Research·Toshihiko FukuchiTeiichi Onuma

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Citations

May 7, 2010·Current Neurology and Neuroscience Reports·Maromi Nei, Ryan Hays
Oct 14, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Karl O Nakken, Erik Taubøll
Nov 19, 2013·Expert Review of Neurotherapeutics·Gauhar A Malik, Phil E M Smith
Oct 22, 2013·Epilepsy & Behavior : E&B·Edward Glasscock
Mar 17, 2015·Epilepsy & Behavior : E&B·Chang ZengHua-Jun Feng
Mar 23, 2011·Epilepsy & Behavior : E&B·Fulvio Alexandre ScorzaRicardo Mario Arida
Oct 27, 2009·Neurologic Clinics·Lina Nashef, Philippe Ryvlin
Jul 21, 2009·Epilepsy & Behavior : E&B·Fulvio A ScorzaEsper A Cavalheiro
May 2, 2009·Epilepsy & Behavior : E&B·Claire M Lathers
Oct 2, 2015·Epilepsy Research·Brian D Moseley, Christopher M DeGiorgio
Mar 19, 2014·Seizure : the Journal of the British Epilepsy Association·Rohit ShankarScott Brown
Aug 9, 2011·Pacing and Clinical Electrophysiology : PACE·Samuel G WittekindMohan N Viswanathan
Oct 4, 2012·Epilepsia·Torbjörn TomsonRobert Leadbetter
Dec 14, 2011·IEEE Transactions on Bio-medical Engineering·Isa ConradsenHelge B D Sorensen
Jun 24, 2014·Seizure : the Journal of the British Epilepsy Association·Alberto VerrottiSalvatore Grosso
Jun 17, 2015·Seizure : the Journal of the British Epilepsy Association·Michelle BellonFiona Rillotta
Aug 22, 2013·Seizure : the Journal of the British Epilepsy Association·Rohit ShankarBrendan McLean
Aug 15, 2015·Epilepsy & Behavior : E&B·Hua-Jun Feng, Carl L Faingold
Jun 10, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Anto Bagić
May 13, 2011·Epilepsy Research·Brian D MoseleyJeffrey Britton
Aug 15, 2014·International Journal of Legal Medicine·Sara PartemiRamon Brugada
Oct 27, 2012·Epilepsy & Behavior : E&B·Brian MoseleyChrysostomos P Panayiotopoulos
Jan 11, 2011·Epilepsy & Behavior : E&B·Gulce Unal YildizNurhan Ilhan
Nov 18, 2011·Epilepsy & Behavior : E&B·C M LathersP L Schraeder
Dec 25, 2010·Seizure : the Journal of the British Epilepsy Association·M LanzA Schulze-Bonhage
Apr 12, 2014·Epilepsy Research·Brian D Moseley, Jeffrey W Britton
Dec 3, 2014·Seizure : the Journal of the British Epilepsy Association·Charlotte YoungRichard Hillier
Jul 16, 2013·Respiratory Physiology & Neurobiology·Franck Kalume
Feb 2, 2016·Epilepsy & Behavior : E&B·Rajesh Ramachandran NairSonya Strohm
Aug 3, 2001·Pediatric Neurology·G N Breningstall
Jun 1, 2010·Continuum : Lifelong Learning in Neurology·Hamada Hamid, Ruth Nass
Oct 19, 2016·Journal of Neuroscience Research·Volkan Coskun, Dawn M Lombardo
Nov 21, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Niravkumar Barot, Maromi Nei
Jun 23, 2020·Journal of Caffeine and Adenosine Research·Fabio C TescarolloDetlev Boison
May 15, 2021·Frontiers in Veterinary Science·Enrice HuenerfauthAndrea Tipold
May 31, 2021·Epilepsy & Behavior : E&B·Vahid EslamiCharles Ákos Szabó
Aug 4, 2021·Autonomic Neuroscience : Basic & Clinical·Maromi Nei, Allyson Pickard

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