PMID: 7544075Jul 7, 1995Paper

A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide

Annals of the New York Academy of Sciences
K W Wucherpfennig, D A Hafler

Abstract

Understanding the immune response to myelin antigens in regard to the peptide/MHC/TCR complex is important in defining pathogenesis of demyelinating autoimmune diseases and in developing antigen-specific therapies. We previously reported that individual multiple sclerosis patients may use certain dominant TCR V beta chains to recognize immunodominant MBP peptides. In examining the TCR beta chain usage, we observed repeated TCR VDJ sequences among different T-cell lines isolated from the same patient. This suggested that a few expanded T-cell clones may dominate the immune response to immunodominant MBP peptides. Here, we report experiments where TCR rearrangements were used as a probe for the clonal origin of MBP specific T-cells cultured from blood lymphocytes of MS patients and normal subjects. In two patients with the DR2 haplotype that were analyzed in detail, the T-cell response to MBP was focused on the MBP (84-102) peptide and in vivo expanded population(s) dominated the response to the MBP (84-102) peptide. Two MBP (84-102) specific T-cell clones from a normal subject with the DR2 haplotype were also found to have identical TCR sequences. Clonality was proven by demonstrating that independent clones had identical TCR al...Continue Reading

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Citations

Feb 21, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Dimitrios Karussis
Jun 1, 1996·Blood Reviews·J SchultzeJ G Gribben
Dec 25, 2002·Journal of Clinical Pathology·E HodgesJ L Smith
Apr 3, 2014·Journal of Neuroimmunology·Dan M WaidDavid H Wagner
Nov 16, 2013·Nature Chemical Biology·Jacques Neefjes, Huib Ovaa
Apr 30, 2013·Expert Review of Neurotherapeutics·Dimitrios KarussisIbrahim Kassis
Sep 9, 2008·Expert Opinion on Biological Therapy·Felix I L Clanchy, Richard O Williams
Apr 9, 2015·Frontiers in Immunology·Colleen Elizabeth HayesFaye E Nashold
Aug 14, 2008·PloS One·Johann PötzlAnja Lechner
Feb 3, 2012·PloS One·Cristina Maria CostantinoDavid A Hafler
Feb 1, 1996·Baillière's Clinical Rheumatology·M F Kagnoff
Apr 2, 2014·BioMed Research International·Franca Maria TuccilloGiuseppe Scala
Jun 20, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Rohit Bakshi
Mar 10, 1999·The American Journal of Physiology·L J SaubermannR S Blumberg
Jun 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph CantorMark H Ginsberg
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura DiluvioJoerg C Prinz

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