A review of telavancin in the treatment of complicated skin and skin structure infections (cSSSI).

Therapeutics and Clinical Risk Management
Lala M DunbarRobert M Manausa

Abstract

Telavancin is a novel antibiotic being investigated for the treatment of serious infections caused by Gram-positive bacteria, including complicated skin and skin structure infections (cSSSI) and pneumonia. This once-daily intravenous lipoglycopeptide exerts rapid bactericidal activity via a dual mechanism of action. It is intended for use to combat infections caused by Staphylococcus aureus and other Gram-positive bacteria, including methicillin-resistant and vancomycin-intermediate strains of S. aureus (MRSA and VISA, respectively). Vancomycin is the current gold standard in treating serious infections caused by Gram-positive bacteria, especially MRSA. In recent clinical trials, telavancin has shown excellent efficacy in phase II and III multinational, randomized, double-blinded studies of cSSSI. In the phase II FAST 2 study, which compared telavancin 10 mg/kg intravenously q 24 h vs standard therapy (an antistaphylococcal penicillin at 2 g IV q 6 h or vancomycin 1 gm IV q 12 h), the clinical success rate in the telavancin-treated group was 96% vs 94% in the standard therapy group. In two identical phase III trials comparing telavancin versus vancomycin at the doses of the FAST 2 study for cSSSI, the clinical cure rates were 8...Continue Reading

Citations

Nov 26, 2009·Expert Opinion on Pharmacotherapy·Pornpan KoomanachaiDavid P Nicolau
Apr 14, 2010·Antimicrobial Agents and Chemotherapy·Rodrigo E MendesRonald N Jones
May 28, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xufen Yu, Dianqing Sun
Jul 21, 2010·The Nurse Practitioner·Jennifer M Belavic
Jul 15, 2015·Expert Review of Anti-infective Therapy·Karl Evans R HensonDonald P Levine

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