A review of the cardiovascular and breast actions of drospirenone in preclinical studies

Climacteric : the Journal of the International Menopause Society
T Simoncini, A R Genazzani

Abstract

Hormone therapy is effective for the relief of menopausal symptoms. For women with a uterus, addition of a progestogen is required to protect the endometrium. However, synthetic progestins differ in certain pharmacological characteristics that may have implications for clinical practice. This literature-based review explores differences in the preclinical and clinical profiles of the progestins used in hormone therapy, focusing on their effects on the cardiovascular system and breast. Studies included are selected based on criteria of relevance, topicality, and subjective assessment of quality, following comprehensive searches of online databases. The biological actions of progestins depend on their receptor binding affinity profiles as well as their specific effects on progesterone receptor signaling, which often differ based on the ligand. Observational studies indicate that hormone therapies which include medroxyprogesterone acetate and certain other progestins may attenuate the cardiovascular benefits of estrogen and add to risk of breast cancer. Appraisal of the evidence suggests these clinical effects correlate with the progestin's pharmacological profile. Among the newer progestins, drospirenone has been investigated ext...Continue Reading

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Citations

Feb 15, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cristina VassalleFaustino R Pérez-López
Apr 8, 2011·Climacteric : the Journal of the International Menopause Society·S-Q LinX-J Dong
Mar 28, 2013·Climacteric : the Journal of the International Menopause Society·A R GenazzaniK Gude
Dec 1, 2010·Hormone Molecular Biology and Clinical Investigation·Paolo MannellaAndrea Riccardo Genazzani

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