A Review of the Cytokine IL-17 in Ocular Surface and Corneal Disease

Current Eye Research
K B Garbutcheon-SinghV Calder

Abstract

Aim: To investigate the role of interleukin-17 in ocular surface and corneal disease. Ocular surface and corneal disease is a leading cause of blindness and is an ongoing challenge for the public health sector to implement effective therapies. The majority of cells in corneal lesions are derived primarily from neutrophils that induce inflammatory events that lead to tissue damage. One of the key pro-inflammatory cytokines is IL-17, and it has been investigated in order to facilitate the understanding of the pathogenesis of ocular surface lesion development. Method: A review of the literature was performed through a systematic approach. Results: IL-17 has been shown to exacerbate dry eye disease, viral and bacterial keratitis lesion severity, although it was found to be protective for Acanthamoeba. Antibodies developed to neutralize IL-17 have shown some promise in reducing the severity of some diseases. Conclusion: IL-17 plays a role in the pathogenesis of ocular surface and corneal disease and targeting this cytokine may provide a useful treatment option in the future.

References

Jun 1, 1996·The Journal of Experimental Medicine·F FossiezS Lebecque
Nov 1, 1996·Cornea·E J CohenP R Laibson
Dec 24, 1997·American Journal of Ophthalmology·O D ScheinS West
Mar 25, 1999·Cornea·E J Holland, G S Schwartz
Sep 27, 2000·The British Journal of Ophthalmology·S SharmaG N Rao
Aug 23, 2002·International Ophthalmology Clinics·John P WhitcherMadan P Upadhyay
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeroen MaertzdorfGeorges M G M Verjans
Dec 31, 2002·Investigative Ophthalmology & Visual Science·Steven YehStephen C Pflugfelder
Mar 10, 2004·Archives of Ophthalmology·Scot E MossBarbara E K Klein
Jun 30, 2006·Progress in Retinal and Eye Research·Stephen Kaye, Anshoo Choudhary
Aug 24, 2006·JAMA : the Journal of the American Medical Association·Douglas C ChangUNKNOWN Fusarium Keratitis Investigation Team
Nov 14, 2007·Journal of Leukocyte Biology·Sara J Molesworth-KenyonRobert N Lausch
Nov 24, 2007·Seminars in Immunology·Thomas KornEstelle Bettelli
Dec 21, 2007·Microbiology and Immunology·Goro Matsuzaki, Masayuki Umemura
Jul 2, 2008·The Journal of Experimental Medicine·Cindy S MaMatthew C Cook
Jul 2, 2008·The Journal of Experimental Medicine·Ludovic de BeaucoudreyJean-Laurent Casanova
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jill F WrightBeatriz M Carreno
Sep 25, 2008·Cornea·Thomas GaujouxVincent M Borderie
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sunil K ChauhanReza Dana
Feb 27, 2009·Mucosal Immunology·C S De PaivaS C Pflugfelder
May 19, 2009·Nature Immunology·William O'ConnorRichard A Flavell
Jun 11, 2009·Cornea·Ula JurkunasKathryn Colby
Jul 21, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thomas Hartung, George Daston
Dec 17, 2009·Seminars in Immunopathology·Allen W Ho, Sarah L Gaffen
Apr 30, 2010·The Ocular Surface·Noorjahan Panjwani
May 21, 2010·Mucosal Immunology·M E SternS C Pflugfelder
Jun 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshiyuki MiyazakiHiroki Yoshida
Oct 12, 2010·Science Translational Medicine·Wolfgang HueberFranco Di Padova
Dec 24, 2010·Virulence·Susan R HeimerMichael Gilmore
Dec 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naveen K RajasagiBarry T Rouse
Jan 6, 2011·FEMS Immunology and Medical Microbiology·Jialin LiuHuanying Wan
Feb 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amol SuryawanshiBarry T Rouse
Feb 26, 2011·Immunity·Yoichiro IwakuraSusumu Nakae
Jul 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amol SuryawanshiBarry T Rouse
Sep 13, 2011·Blood·Sunil K ChauhanReza Dana

❮ Previous
Next ❯

Citations

Sep 24, 2020·Antioxidants·Ana Karen López-ContrerasAdolfo Daniel Rodríguez-Carrizalez
Apr 2, 2021·Therapeutics and Clinical Risk Management·Yi-Fang MengXin-Yu Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Korean Medical Science
Min Ho KangJin Hak Lee
Arerugī = [Allergy]
Trends in Molecular Medicine
Audrey BeringerPierre Miossec
European Journal of Dermatology : EJD
Mattias Fischer-StabauerKilian Eyerich
© 2022 Meta ULC. All rights reserved