A review of the effects of the anesthetic gas nitrous oxide on the immune system; a starting point for future experiences

Immunopharmacology and Immunotoxicology
Monireh MohsenzadeganShahnam Sedigh Maroufi

Abstract

Nitrous oxide is a common gas used as an anesthetic agent and analgesic medication in operating rooms. The gas inhibits vitamin B12 dependent-methionine synthase, which converts L-homocysteine and 5-methyltetrahydrofolate to L-methionine and tetrahydrofolate, respectively, via a methylation process. The immune system has been frequently reported to be suppressed in anesthetized subjects during the postoperative period. Although previous reviews have focused on the pathophysiologic role of nitrous oxide, none of them has considered the harmful effects of nitrous oxide on the Defense system of the host. In this article, the authors review current studies on the effects of nitrous oxide on the immune system of both patients undergoing surgery and occupational exposure, as well as preclinical studies. Moreover, this paper opens a new horizon for future studies in the context of underlying mechanisms of nitrous oxide actions on the immune system.

References

Jan 1, 1990·Toxicology and Industrial Health·C E HealyR P Sharma
Feb 18, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N FukuharaO Nakanishi
Feb 27, 1999·Toxicology Letters·D FröhlichK Taeger
Sep 3, 1999·Occupational and Environmental Medicine·K HoeraufM Nüsse
May 1, 2001·The Science of the Total Environment·A BargelliniP Borella
May 20, 2003·Best Practice & Research. Clinical Anaesthesiology·Jörg Weimann
Sep 29, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Daniel BunoutCarlos Muñoz
Oct 20, 2004·Trends in Pharmacological Sciences·Nicholas P Franks, Eric Honoré
Aug 27, 2005·European Journal of Anaesthesiology·C E SchneemilchU Bank
Mar 14, 2007·Anesthesia Progress·Dimitris E Emmanouil, Raymond M Quock
Aug 9, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dimitris E EmmanouilRaymond M Quock
Feb 22, 2008·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Mehmet Ali ErkurtAhmet Sonmez
Sep 3, 2008·Immunopharmacology and Immunotoxicology·Abbas Mirshafiey, Monireh Mohsenzadegan
Sep 25, 2008·Anesthesiology·Robert D SandersMervyn Maze
Oct 22, 2008·Brain Research·Jens LehmbergEberhard Uhl
Jan 21, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·B KocerM Yilmaz
Sep 3, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Coskun MinnetAbdurrahim Kocyigit
Nov 17, 2011·Mutation Research·Teresa Wrońska-NoferKonrad Rydzyński
Feb 22, 2012·Biochemistry. Biokhimii︠a︡·A A BoldyrevE A Vladychenskaya
Sep 1, 2015·Frontiers in Pharmacology·Angela Scanzano, Marco Cosentino
Oct 16, 2015·Nature Reviews. Cardiology·Kristen E CosselmanJoel D Kaufman
Oct 27, 2015·Regulatory Toxicology and Pharmacology : RTP·Jan van AmsterdamWim van den Brink
Dec 3, 2015·European Journal of Anaesthesiology·Pierre A DiemunschGirish P Joshi
Feb 26, 2016·Journal of Psychopharmacology·Stephen J KaarAdam R Winstock
Jul 28, 2016·Brain Research·Masoumeh Kourosh AramiSaeed Semnanian
Sep 28, 2016·Wiener medizinische Wochenschrift·Stefanie Kulnigg-Dabsch
Mar 10, 2017·Scandinavian Journal of Gastroenterology·Vincenzo VillanacciGabrio Bassotti
Apr 6, 2017·Turkish Journal of Anaesthesiology and Reanimation·Daniel I Sessler
Apr 30, 2017·Results and Problems in Cell Differentiation·Martin LeeJonathan Choy
Sep 26, 2017·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Marcos Antônio Thereza-FilhoJanaína L Narciso-Schiavon
Jun 1, 2018·The Lancet. Planetary Health·Michael Charlesworth, Frank Swinton
Jan 25, 2019·Current Drug Targets·Farhad SeifMonireh Mohsenzadegan
May 12, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·S M Matt, P J Gaskill
Jul 30, 2019·Frontiers in Neurology·Jowy TaniCindy Shin-Yi Lin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Dental Science
The American Journal of Dental Science
R N Hudson
The American Journal of Dental Science
H J Barnes
The Journal of the American Dental Association
R Boyum
The Journal of the American Dental Association
F Quarnstrom
© 2021 Meta ULC. All rights reserved