A review of the epidemiological evidence for the 'antioxidant hypothesis'

Public Health Nutrition
S A StannerJ Buttriss


The British Nutrition Foundation was recently commissioned by the Food Standards Agency to conduct a review of the government's research programme on Antioxidants in Food. Part of this work involved an independent review of the scientific literature on the role of antioxidants in chronic disease prevention, which is presented in this paper. There is consistent evidence that diets rich in fruit and vegetables and other plant foods are associated with moderately lower overall mortality rates and lower death rates from cardiovascular disease and some types of cancer. The 'antioxidant hypothesis' proposes that vitamin C, vitamin E, carotenoids and other antioxidant nutrients afford protection against chronic diseases by decreasing oxidative damage. Although scientific rationale and observational studies have been convincing, randomised primary and secondary intervention trials have failed to show any consistent benefit from the use of antioxidant supplements on cardiovascular disease or cancer risk, with some trials even suggesting possible harm in certain subgroups. These trials have usually involved the administration of single antioxidant nutrients given at relatively high doses. The results of trials investigating the effect of...Continue Reading


Aug 8, 1992·BMJ : British Medical Journal·S E HankinsonWalter C Willett
Dec 5, 1992·BMJ : British Medical Journal·P KnektR K Aaran
Jan 1, 1992·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·J M GardinT A Manolio
Dec 1, 1991·The American Journal of Clinical Nutrition·G Block
Dec 1, 1990·International Journal of Epidemiology·R BeagleholeR L Yee
Apr 4, 1990·Journal of the National Cancer Institute·G R HoweT Rohan
May 16, 1990·Journal of the National Cancer Institute·P KnektL Teppo
Mar 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·N BishopJ K Wales
May 1, 1987·The American Journal of Clinical Nutrition·K F GeyH B Stähelin
Jan 1, 1987·American Journal of Epidemiology·F J KokH A Valkenburg
Jun 1, 1985·The Journal of Nutrition·G J HandelmanE A Dratz
Aug 1, 1985·American Journal of Epidemiology·J VirtamoM J Karvonen
Apr 1, 1973·Journal of the National Cancer Institute·R J ShambergerC E Willis
Oct 1, 1980·The American Journal of Clinical Nutrition·J Ramirez, N C Flowers
Dec 1, 1995·The American Journal of Clinical Nutrition·W J BlotB Li
Dec 1, 1995·The American Journal of Clinical Nutrition·A TaylorE M Epstein
Dec 15, 1995·The American Journal of Cardiology·S SalviniM J Stampfer
Jun 21, 1995·JAMA : the Journal of the American Medical Association·H N HodisS P Azen
Feb 15, 1995·American Journal of Epidemiology·J A Mares-PerlmanS M Shoff
Feb 27, 1995·Archives of Internal Medicine·M G HertogS Nedeljkovic
Mar 1, 1995·The American Journal of Clinical Nutrition·G E Hatch
Sep 24, 1994·Lancet·P A Cerutti
Jul 21, 1994·The New England Journal of Medicine·E R GreenbergR W Haile
Apr 14, 1994·The New England Journal of Medicine·Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
Dec 31, 1993·Annals of the New York Academy of Sciences·J Michael Gaziano, C H Hennekens
Jun 15, 1994·American Journal of Epidemiology·P KnektA Aromaa
Feb 1, 1994·Archives of Ophthalmology·S WestN M Bressler
Jul 1, 1993·American Journal of Epidemiology·I MiedemaD Kromhout
Aug 1, 1993·Journal of the American College of Nutrition·JoAnn E MansonC H Hennekens
May 20, 1993·The New England Journal of Medicine·M J StampferWalter C Willett
May 20, 1993·The New England Journal of Medicine·E B RimmWalter C Willett
Jan 27, 1996·Lancet·P M Rowe


Dec 26, 2013·Amino Acids·Javier A Miret, Sergi Munné-Bosch
Oct 6, 2007·Breast Cancer Research and Treatment·Tsogzolmaa DorjgochooWei Zheng
Jan 23, 2014·Advanced Drug Delivery Reviews·Christoph Giese, Uwe Marx
Oct 2, 2008·The British Journal of Nutrition·S Honarbakhsh, M Schachter
May 1, 2008·The British Journal of Nutrition·Minoru SugiuraMasamichi Yano
May 1, 2013·Critical Reviews in Food Science and Nutrition·Anthony Fardet, Jean-Michel Chardigny
Jan 1, 2009·Journal of the National Cancer Institute·Jennifer LinJoAnn E Manson
Oct 12, 2010·Clinical Microbiology Reviews·Lydia E WroblewskiKeith T Wilson
Dec 23, 2011·Oxidative Medicine and Cellular Longevity·B Poljsak
Jun 6, 2013·Oxidative Medicine and Cellular Longevity·Borut PoljsakIrina Milisav
May 14, 2009·Plant Foods for Human Nutrition·A F de FariaA Z Mercadante
Jul 6, 2014·BioMed Research International·Mayron Alves VasconcelosEdson Holanda Teixeira
Jan 1, 2013·Jundishapur Journal of Natural Pharmaceutical Products·Mohaddese MahboubiAli Reza Boland Nazar
Mar 24, 2005·Progress in Cardiovascular Nursing·Donna J Drown
Jan 13, 2009·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Empfehlung des Robert Koch-Instituts
Jun 27, 2014·International Journal of Molecular Sciences·Bin LiHong-Yu Zhang
Dec 13, 2006·Expert Opinion on Investigational Drugs·Graziano RiccioniNicolantonio D'Orazio
Jul 28, 2013·Journal of the Academy of Nutrition and Dietetics·Kristi M CroweAcademy of Nutrition and Dietetics
Sep 15, 2012·European Journal of Pharmacology·Nitya V JaniChristine E Wright
Apr 13, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J KarppiS Kurl
Jun 15, 2011·Free Radical Biology & Medicine·Maret G Traber, Jan F Stevens
Nov 4, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C A HoughtonJ S Coombes
Apr 24, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Satyakumar Vidyashankar, Pralhad Sadashiv Patki
Jul 28, 2009·Mechanisms of Ageing and Development·Thorsten PetersKarin Scharffetter-Kochanek
Oct 18, 2008·Mutation Research·Michelle Andrade FurtadoDenise Crispim Tavares
May 11, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Haider Raza, Annie John
Mar 27, 2007·Biochemical Pharmacology·Gian Luigi Russo
Mar 9, 2005·Annals of the New York Academy of Sciences·Lucilla PostonFrank Kelly
Jul 18, 2006·Alimentary Pharmacology & Therapeutics·G BjelakovicC Gluud
Jan 16, 2009·Alimentary Pharmacology & Therapeutics·G BjelakovicC Gluud
Oct 8, 2008·Annals of the New York Academy of Sciences·Haider Raza, Annie John

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