A review of the incidence and coincidence of uterine and mammary tumors in Wistar and Sprague-Dawley rats based on the RITA database and the role of prolactin

Toxicologic Pathology
Johannes H HarlemanSarah Kirk

Abstract

Wistar rats are frequently selected for use in carcinogenicity studies because of their advantageous survival rate, which is more favorable than other strains such as the Sprague-Dawley (SD) strain. Uterine and mammary tumors are relatively common spontaneous neoplasms of both strains. We examined the incidence and coincidence of uterine tumors and mammary tumors in control animals of both strains within the RITA database. There was a strong inverse relationship between these tumor types in Wistar rats (p < .001). A less strong relationship was present in SD rats (p = .057). This association is likely to be related to prolactin. A short review of the role of prolactin in rats is given. These results are also discussed in the background of nonspecific toxicity at high dose levels in carcinogenicity studies above MTD levels resulting in reduction in body weights of >10%.

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Citations

Nov 19, 2013·Progress in Biophysics and Molecular Biology·Shuguang Yu, Peng Shang
Dec 15, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Terri L Mitchard, Stephanie Klein
Nov 6, 2015·Journal of Toxicologic Pathology·Midori YoshidaMiwa Takahashi
Jan 3, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·R R MaronpotB Hansen
Oct 30, 2016·Regulatory Toxicology and Pharmacology : RTP·Dana L ShueyAlan Roberts
Oct 16, 2016·Journal of Radiation Research·Kaye ShowlerYoshiya Shimada
Jul 15, 2015·Toxicologic Pathology·Cynthia J WillsonJ Mark Cline
Feb 13, 2018·International Journal of Cancer. Journal International Du Cancer·Kazuhiro DainoShizuko Kakinuma

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