A review of the molecular mechanisms of hyperglycemia-induced free radical generation leading to oxidative stress

Journal of Cellular Physiology
Habib YaribeygiAmirhossein Sahebkar

Abstract

The prevalence of diabetes is growing worldwide with an increasing morbidity and mortality associated with the development of diabetes complications. Free radical production is a normal biological process that is strictly controlled and has been shown to be important in normal cellular homeostasis, and in the bodies response to pathogens. However, there are several mechanisms leading to excessive free radical production that overcome the normal protective quenching mechanisms. Studies have shown that many of the diabetes complications result from excessive free radical generation and oxidative stress, and it has been shown that chronic hyperglycemia is a potent inducer for free radical production, generated through several pathways and triggering multiple molecular mechanisms. An understanding of these processes may help us to improving our preventive or therapeutic strategies. In this review, the major molecular pathways involved in free radical generation induced by hyperglycemia are described.

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Citations

Oct 15, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Jan 10, 2019·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Mar 3, 2019·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Dec 12, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Feb 13, 2019·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Feb 14, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Laura E Gutiérrez-PliegoRoxana Valdés-Ramos
May 28, 2019·Antioxidants·María Pilar de TorreJosé Luis Vizmanos
Mar 10, 2020·Oxidative Medicine and Cellular Longevity·Jeremiah Oshiomame Unuofin, Sogolo Lucky Lebelo
Jan 31, 2020·Neural Regeneration Research·Jose A Fernández-AlbarralJuan J Salazar
Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Habib YaribeygiAmirhossein Sahebkar
Nov 15, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Jul 23, 2020·Anais Da Academia Brasileira De Ciências·PatrÍcia MolzSilvia I R Franke
Oct 9, 2020·Journal of Food Biochemistry·Claudia I Gamboa-GómezLuis E Simental-Mendía
Nov 2, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Fulya ErendorSalih Sanlioglu
Sep 11, 2020·Canadian Journal of Physiology and Pharmacology·Ekaterina V SilinaSergey B Bolevich
Jan 20, 2021·Clinical and Experimental Pharmacology & Physiology·Fateme KooshkiBahram Pourghassem Gargari
Jan 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wan Seok KangJunghyun Kim
Jan 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Renner Philipe Rodrigues CarvalhoMariana Machado-Neves
Dec 10, 2020·Journal of Diabetes Research·Habib YaribeygiAmirhossein Sahebkar
Feb 13, 2021·Developmental Biology·Haruko NakanoAtsushi Nakano
Mar 13, 2021·Frontiers in Physiology·Jose A AdamsMarvin A Sackner
Jul 2, 2021·Journal of Traditional and Complementary Medicine·Babalola Ola YusufMusbau Adewumi Akanji
Aug 18, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Tokiko SuzukiYuichi Hattori
Nov 10, 2020·ACS Omega·Aima Iram BatoolMuhammad Fayyaz Ur Rehman
Jan 22, 2019·Journal of Agricultural and Food Chemistry·Nunzia D'OnofrioGiuseppe Campanile
Dec 3, 2021·Cell Biochemistry and Function·Salma M ErakyNada F Abo El-Magd

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