A Review of the Ongoing Research on Zika Virus Treatment

Viruses
Suely da SilvaAna Carolina Gomes Jardim

Abstract

The Zika fever is an arboviral disease resulting from the infection with Zika virus (ZIKV). The virus is transmitted to humans by the bite of Aedes mosquitos, mainly Aedes aegypti and Aedes albopictus. ZIKV has been detected for decades in African and Asian regions and, since 2007, has spread to other continents; among them, infections are most reported in the Americas. This can be explained by the presence of vectors in highly populated and tropical regions where people are susceptible to contamination. ZIKV has been considered by the World Health Organization a serious public health problem because of the increasing number of cases of congenital malformation and neurological disorders related to its infection, such as microcephaly, Guillain⁻Barré syndrome, meningoencephalitis, and myelitis. There is no vaccine or specific antiviral against ZIKV. The infection is best prevented by avoiding mosquito bite, and the treatment of infected patients is palliative. In this context, the search for efficient antivirals is necessary but remains challenging. Here, we aim to review the molecules that have been described to interfere with ZIKV life cycle and discuss their potential use in ZIKV therapy.

References

Jan 1, 1990·Annual Review of Microbiology·T J ChambersC M Rice
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·J G Olson Triwibowo
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·M A DarwishF Omar
Feb 24, 2001·Nucleosides, Nucleotides & Nucleic Acids·E De Clercq
Jan 30, 2003·The Journal of Biological Chemistry·Steven S CarrollDavid B Olsen
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICK
Sep 3, 2004·Bioorganic & Medicinal Chemistry Letters·Shuli MaoDennis C Liotta
Jun 28, 2005·Antimicrobial Agents and Chemotherapy·Brenda I Hernandez-SantiagoRaymond F Schinazi
Sep 3, 2005·Antiviral Research·Jae-Min SongBaik-Lin Seong
May 9, 2007·Antimicrobial Agents and Chemotherapy·Ghazia AsifRaymond F Schinazi
Jan 16, 2008·Antimicrobial Agents and Chemotherapy·Charles E IsaacsSharon Hillier
Feb 11, 2009·The Journal of Allergy and Clinical Immunology·Christina L NanceWilliam T Shearer
May 20, 2009·Microbes and Infection·C PaupyD Fontenille
Jun 12, 2009·The New England Journal of Medicine·Mark R DuffyEdward B Hayes
Dec 1, 2009·Antiviral Research·Michela BollatiMartino Bolognesi
Mar 6, 2012·PLoS Neglected Tropical Diseases·Andrew D HaddowScott C Weaver
Dec 4, 2012·Viruses·Noémie CallandKarin Séron
Aug 1, 2013·Physiological Reviews·Paul N Hopkins
Aug 13, 2013·PLoS Neglected Tropical Diseases·Pei-Sze Jeslyn WongCheong-Huat Tan
Oct 1, 2013·Journal of Molecular Biology·Jill M PerreiraAbraham L Brass
Apr 18, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·D MussoJ Broult
Oct 24, 2014·Emerging Infectious Diseases·W Thane HancockMartin Bel
Jun 24, 2015·The American Journal of Tropical Medicine and Hygiene·Rome BuathongTanarak Plipat
Nov 14, 2015·Expert Opinion on Drug Discovery·Ivan GentileGuglielmo Borgia
Dec 18, 2015·Blood Transfusion = Trasfusione Del Sangue·Giuseppe MaranoGiuliano Grazzini
Jan 8, 2016·Antiviral Research·Sandra SöderholmDenis Kainov
Jan 23, 2016·PLoS Neglected Tropical Diseases·Elodie CalvezMyrielle Dupont-Rouzeyrol
Feb 4, 2016·Arquivos brasileiros de oftalmologia·Camila V VenturaLiana O Ventura
Feb 6, 2016·BMJ : British Medical Journal·Michael McCarthy
Feb 8, 2016·Lancet·Udani Samarasekera, Marcia Triunfol
Feb 9, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Eskild PetersenAlimuddin Zumla
Mar 5, 2016·The Journal of Infection·Jasper F W ChanKwok-Yung Yuen
Mar 31, 2016·The New England Journal of Medicine·Lyle R PetersenMargaret A Honein
Apr 2, 2016·Science·Devika SirohiRichard J Kuhn
Apr 20, 2016·Cell Host & Microbe·Lulan WangGenhong Cheng
May 18, 2016·Antiviral Research·Fumihiro KatoTakayuki Hishiki
May 22, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rengina Vorou
May 29, 2016·The Journal of Infectious Diseases·Luděk EyerDaniel Růžek
Jun 10, 2016·Virology Journal·Formijn van Hemert, Ben Berkhout

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Citations

Feb 26, 2019·Journal of Medical Virology·Yingshan HanThibault Mesplède
Mar 22, 2019·Journal of Virology·Angelica Cifuentes KottkampKenneth A Stapleford
Sep 20, 2019·Journal of Virology·Blandine MonelOlivier Schwartz
Jan 23, 2019·Frontiers in Microbiology·Kirill GorshkovAlexey V Terskikh
Jul 31, 2019·Nucleic Acids Research·Shan XuLei Shi
Jul 25, 2019·Frontiers in Cellular and Infection Microbiology·Megan ChesnutDavid Pamies
Jun 11, 2019·Annual Review of Virology·Dawn M DudleyDavid H O'Connor
Nov 16, 2018·Expert Opinion on Investigational Drugs·Yingshan Han, Thibault Mesplède
Jun 4, 2019·Microbes and Infection·Pauline FerrarisDorothée Missé

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Methods Mentioned

BETA
flow cytometry
enzyme-linked immunosorbent assay
PCR
AlphaScreen

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