A review of the role of atrial natriuretic peptide gene polymorphisms in hypertension and its sequelae.

Current Hypertension Reports
Amy I LynchDonna K Arnett

Abstract

The natriuretic peptide precursor A (NPPA) gene, found on chromosome 1p36, encodes the precursor from which atrial natriuretic polypeptide (ANP) is derived. Due to the action of ANP, it is thought that the NPPA gene is involved in the control of blood pressure. Animal studies have shown that genetically reduced ANP concentration leads to salt-sensitive hypertension, whereas genetically increased ANP concentration leads to hypotension. These studies have encouraged researchers to search the human NPPA gene for polymorphisms that contribute to hypertension and its sequelae such as stroke and cardiovascular disease. This report provides a comprehensive review of studies exploring NPPA polymorphisms in relation to hypertension and hypertension-related outcomes.

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Citations

Nov 15, 2013·European Heart Journal·Massimo VolpeJohn Burnett
Feb 28, 2013·American Journal of Medical Genetics. Part a·Tanya GuptaEdward J Lammer
Aug 11, 2015·Nature Medicine·Shenghan ChenQingyu Wu
May 12, 2012·Journal of the American College of Cardiology·Emanuele BarbatoSperanza Rubattu
Jan 12, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Zhengbao ZhuYonghong Zhang
Oct 5, 2013·Clinical Medicine Insights. Cardiology·Pietro FranciaMassimo Volpe
Apr 27, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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