A review of the toxicity of Lantana camara (Linn) in animals

Clinical Toxicology
Om P SharmaS S Negi

Abstract

Lantana poisoning has been taking a heavy toll of livestock year after year. All aspects of the problem are reviewed. Lantana poisoning in cattle, sheep, buffalo, and guinea pigs caused obstructive jaundice, photosensitization, and rise in serum glutamicoxaloaetic transaminase activity. The symptoms could be reproduced in sheep by administration of purified Lantadene A. Liver and kidneys are the most affected organs during lantana poisoning. Intoxication of guinea pigs with Lantana camara leads to marked alterations in major tissue constituents in liver an kidneys. Hepatic and renal xanthine oxidase activity is also elevated during lantana poisoning. No antidote is available against the toxic section of Lantana camara. Symptomatic treatments have been proposed with limited success. Knowledge of the biochemical mechanism of lantana intoxication at the cellular, subcellular, and molecular levels is essential in order to evolve a successful antidote and more rational therapy during lantana intoxication.

References

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Citations

May 27, 2010·Indian Journal of Pharmaceutical Sciences·B Sharma, P Kumar
Mar 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Fernanda B MelloJoão R B Mello
Apr 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·O P SharmaR K Dawra
Jan 30, 2014·Toxicon : Official Journal of the International Society on Toxinology·Haroon A ParimooNeeraj Kumar
Apr 25, 2007·Critical Reviews in Toxicology·Om P SharmaPritam D Sharma
Feb 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luiz Marivando BarrosJean Paul Kamdem
Jan 1, 1992·Journal of Biochemical Toxicology·O P SharmaK K Bhutani
Jan 1, 1989·Journal of Chemical Ecology·M SinghH N Nigg
Oct 13, 2005·Phytotherapy Research : PTR·A A AdedapoO O Olorunsogo
Nov 1, 1991·Journal of Chemical Ecology·O P SharmaP D Sharma
May 1, 1984·Chemico-biological Interactions·O P Sharma, R K Dawra
Apr 1, 1982·Toxicology Letters·O P SharmaS S Negi
Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·O P SharmaR K Dawra

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