A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents

Digestive Diseases and Sciences
R E Pemberton, L J Strand

Abstract

Newer nonsteroidal antiinflammatory agents (NSAI's) such as ibuprofen, neproxen, fenoprofen, and tolmetin have broadened the therapeutic choice and increased the chances of providing optimum arthritis control, but require careful assessment of the possibilities for unwanted drug effects when long-term therapy is required. A review of the literature on the gastrointestinal effects of the promising newer NSAIs, as compared with the older agents, aspirin, indomethacin, and phenylbutazone, is presented, highlighting animal toxicology and human adverse reaction surveillance data and the evidence for various suggested pathophysiological mechanisms.

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Related Concepts

Metazoa
Analgesics, Anti-Inflammatory
Rheumatoid Arthritis
Micristin
Clinical Trials
Diclonate P
Double-Blind Method
Drug Evaluation
Fenoprofen, Anhydrous, Calcium Salt
Structure of Pyloric Gland

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