A review of vaccine research and development: the human immunodeficiency virus (HIV)

Vaccine
Marc P GirardMarie Paule Kieny

Abstract

Since the discovery of AIDS in 1981, the global spread of HIV has reached pandemic proportions, representing a global developmental and public health threat. The development of a safe, globally effective and affordable HIV vaccine offers the best hope for the future control of the pandemic. Significant progress has been made over the past years in the areas of basic virology, immunology, pathogenesis of HIV/AIDS and the development of antiretroviral drugs. However, the development of an HIV vaccine faces formidable scientific challenges related to the high genetic variability of the virus, the lack of immune correlates of protection, limitations with the existing animal models and logistical problems associated with the conduct of multiple clinical trials. More than 35 vaccine candidates have been tested in Phase I/II clinical trials, involving more than 10,000 volunteers, and two Phase III trials have been completed, themselves involving more than 7500 volunteers. Multiple vaccine concepts and vaccination strategies have been tested, including DNA vaccines, subunit vaccines, live vectored recombinant vaccines and various prime-boost vaccine combinations. This article reviews the state of the art in HIV vaccine development, sum...Continue Reading

Citations

Mar 19, 2014·Journal of Neurovirology·Fengming LiuXuebin Qin
Jul 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·David P WilsonSally M Blower
May 29, 2010·Journal of Biomedicine & Biotechnology·Ling YeChinglai Yang
Sep 28, 2007·Journal of Virology·Viv Peut, Stephen J Kent
Oct 18, 2007·The Journal of Organic Chemistry·Nardos Teumelsan, Xuefei Huang
Dec 21, 2007·Journal of Immune Based Therapies and Vaccines·Qiu Zhong, Ronald B Luftig
Apr 12, 2008·The New England Journal of Medicine·Barbara S TaylorScott M Hammer
Apr 14, 2011·The Journal of Biological Chemistry·Grégoire MartinLoïc Martin
Jun 8, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laith J Abu-RaddadIra M Longini
Dec 14, 2011·Plant Cell Reports·Sergio Rosales-MendozaLeticia Moreno-Fierros
Feb 28, 2007·Current Infectious Disease Reports·Marianne Mikkelsen, Jens Bukh
Dec 22, 2011·Current Opinion in HIV and AIDS·Fernando MaltêzCristina Valente
Apr 17, 2007·Médecine sciences : M/S·Claude Leclerc
Feb 26, 2009·International Reviews of Immunology·Thorsten Demberg, Marjorie Robert-Guroff
Mar 1, 2008·Expert Opinion on Therapeutic Patents·Tanu ChawlaSathyamangalam Swaminathan
Apr 6, 2007·Expert Review of Vaccines·Matthias LinigerHussein Y Naim
Feb 7, 2008·Expert Review of Vaccines·Andreas Boberg, Maria Isaguliants
Jun 4, 2010·Expert Review of Vaccines·Stephen HeartyRichard O'Kennedy
Jan 1, 2013·Vaccines·José Esparza
Mar 16, 2007·Expert Opinion on Emerging Drugs·Emma J Bishop, Benjamin P Howden
Aug 23, 2008·Drug Delivery·T GovenderI Mackraj
Aug 11, 2010·The American Journal of the Medical Sciences·Susana Chávez-Bueno, Terrence L Stull
May 19, 2009·Annales pharmaceutiques françaises·M P Girard
Sep 15, 2015·International Journal of Biological Macromolecules·Barnabas WilsonJ Josephine Leno Jenita
Jul 29, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Elizabeth OjewoleThirumala Govender
Feb 26, 2008·Veterinary Immunology and Immunopathology·Elizabeth W UhlJanet K Yamamoto
Sep 22, 2007·Advanced Drug Delivery Reviews·H ZappeM J Bossard
Jul 27, 2007·Tuberculosis·Yoshikazu YukiHiroshi Kiyono
May 30, 2009·Journal of Medical Primatology·Nattawan Promadej-LanierRon A Otten
Sep 24, 2009·Journal of Medical Virology·G B JacobsS Engelbrecht

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Anthrax Vaccines (ASM)

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Related Papers

Annual Review of Immunology
Andrew J McMichael
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Ann DuerrLawrence Corey
Nature
Herbert W Virgin, Bruce D Walker
© 2021 Meta ULC. All rights reserved