A review of vaccine research and development: meningococcal disease

Vaccine
Marc P GirardMarie Paule Kieny

Abstract

This paper reviews the current status of research and development of vaccines against meningococcal disease due to Neisseria meningitidis, a major cause of severe meningitis and septicemia with epidemic potential. While five serogroups (A, B, C, Y, and W135) are responsible for most of the disease, Group A remains unique in its ability to cause large scale epidemics mainly in Africa but also in Asia. The majority of cases in Europe and America are due to Groups B and C. The successful experience with Hib and pneumococcal conjugate vaccines has paved the way for the development of polysaccharide conjugate vaccines for the prevention of meningococcal disease. Widespread vaccination with Group C conjugate vaccines now in use in several European countries indicates that these vaccines are immunogenic, induce immunological memory, reduce colonization and provide herd immunity to the general population. A monovalent group A conjugate vaccine being developed at an affordable price, offers hope for the elimination of large epidemics in African countries. Multivalent (A, C, Y, W) conjugate vaccines are being developed, and one has already been licensed. However, effective global prevention of meningococcal disease will not be achievable...Continue Reading

Citations

Sep 16, 2008·Southern Medical Journal·Kjell WibergJeremy Gradon
Jul 20, 2010·Immunotherapy·Anastas PashovThomas Kieber-Emmons
Mar 22, 2014·Chemical Communications : Chem Comm·Van N Tra, Danielle H Dube
Oct 13, 2011·Advances in Preventive Medicine·Jacqueline M MillerYaela Baine
Dec 15, 2010·Seminars in Immunopathology·Can M UnalKristian Riesbeck
Jul 10, 2007·Genome Biology·Gino J E BaartDirk E Martens
Jul 31, 2007·Epidemiology and Infection·C Stein-ZamirC Block
Feb 7, 2009·The Journal of Biological Chemistry·Francesca CantiniRino Rappuoli
Oct 24, 2009·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Mikio Tanabe, Tina M Iverson
Feb 19, 2010·Virology Journal·Marie-Noëlle TakahashiKatherine E Owen
Apr 29, 2011·BMC Public Health·Debajeet ChoudhuriIgor Rudan
Feb 16, 2013·Journal of Proteome Research·Bas van de WaterbeemdAd P J M de Jong
May 8, 2009·Current Opinion in Pediatrics·Kathryn S Brigham, Thomas J Sandora
Sep 1, 2007·Current Opinion in Infectious Diseases·Annelies Wilder-Smith
Aug 22, 2012·Current Opinion in Infectious Diseases·Jakob P Cramer, Annelies Wilder-Smith
Oct 18, 2011·Paediatric Drugs·Shruti Agrawal, Simon Nadel
Mar 30, 2010·Applied Microbiology and Biotechnology·Miguel Angel Ferrero, Leandro Rodríguez Aparicio
Feb 7, 2008·Expert Review of Anti-infective Therapy·Arvind K Bansal
May 25, 2011·Expert Review of Vaccines·Annaliesa S AndersonJoseph Eiden
Jun 3, 2009·Expert Review of Vaccines·Stephen I Pelton, Gregory P Gilmet
Mar 12, 2010·Expert Review of Vaccines·Ameneh Khatami, Andrew J Pollard
Dec 5, 2008·Expert Review of Vaccines·Guilherme Gonçalves
Oct 19, 2007·Expert Review of Proteomics·Giulia BernardiniAnnalisa Santucci
Jun 23, 2009·Expert Review of Vaccines·Caroline L Trotter, Martin C J Maiden
Jul 3, 2013·Expert Opinion on Biological Therapy·Soha GhanemGhassan S Dbaibo
Jan 14, 2016·Journal of Pharmaceutical and Biomedical Analysis·M MordušB Halassy
Nov 2, 2013·Emergency Medicine Clinics of North America·Robyn WingPatricia A McQuilkin
Mar 1, 2012·Journal of Epidemiology and Global Health·Atef ShiblUNKNOWN Meningococcal Leadership Forum (“MLF”) Expert Group
Jan 14, 2016·BMC Research Notes·Sanna HuttunenCarina Tikkanen-Kaukanen
Jan 12, 2016·Human Vaccines & Immunotherapeutics·Giuseppe MurdacaFilippo Ansaldi
Sep 1, 2009·Travel Medicine and Infectious Disease·Mohamed K M Khalil, Ray Borrow
Jun 24, 2008·Travel Medicine and Infectious Disease·Annelies Wilder-Smith

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