A review on bacterial resistance to carbapenems: epidemiology, detection and treatment options

Future Science OA
Ann A Elshamy, Khaled M Aboshanab

Abstract

Carbapenems are a class of antimicrobial agents reserved for infections caused by multidrug-resistant microorganisms. The emergence of carbapenem resistance has become a serious public health threat. This type of antimicrobial resistance is spreading at an alarming rate, resulting in major outbreaks and treatment failure of community-acquired and nosocomial infections caused by the clinically relevant carbapenem-producing Enterobacteriaceae or carbapenem-resistant Enterobacteriaceae. This review is focused on carbapenem resistance, including mechanisms of resistance, history and epidemiology, phenotypic and genotypic detection in the clinically relevant bacterial pathogens and the possible treatment options available.

References

Jan 1, 1991·Antimicrobial Agents and Chemotherapy·M WatanabeS Mitsuhashi
Jan 1, 1966·The Biochemical Journal·L D Sabath, E P Abraham
Mar 4, 2000·Journal of Clinical Microbiology·A TsakrisD M Livermore
Aug 28, 2002·International Journal of Medical Microbiology : IJMM·Fahd K MajiduddinTimothy G Palzkill
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Jan 28, 2005·The New England Journal of Medicine·George A Jacoby, Luisa Silvia Munoz-Price
Apr 16, 2005·Clinical Microbiology Reviews·Timothy R WalshPatrice Nordmann
Jul 4, 2006·American Journal of Infection Control·Fred C Tenover
Jul 4, 2006·American Journal of Infection Control·Neil Fishman
Nov 24, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M E FalagasA Michalopoulos
Dec 13, 2006·Nature Reviews. Drug Discovery·Olga LomovskayaWilliam J Watkins
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy H DellitUNKNOWN Society for Healthcare Epidemiology of America
Jan 31, 2007·Antimicrobial Agents and Chemotherapy·Maria Virginia VillegasUNKNOWN Colombian Nosocomial Resistance Study Group
May 10, 2007·Drugs·George G ZhanelJames A Karlowsky
Jul 17, 2007·Clinical Microbiology Reviews·Anne Marie Queenan, Karen Bush
Jun 4, 2008·Antimicrobial Agents and Chemotherapy·Amélie CarrërPatrice Nordmann
Feb 28, 2009·The Journal of Infection·H C MaltezouA C Vatopoulos
Mar 28, 2009·The Lancet Infectious Diseases·Patrice NordmannThierry Naas
Dec 26, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinJohn G Bartlett
Jun 12, 2010·International Journal of Medical Microbiology : IJMM·Yvonne PfeiferWolfgang Witte
Jul 28, 2010·Antimicrobial Agents and Chemotherapy·Aurora García-FernándezAlessandra Carattoli
Aug 26, 2010·Emerging Infectious Diseases·Gaelle CuzonPatrice Nordmann
Sep 21, 2010·The Journal of Antimicrobial Chemotherapy·María Rosa Gómez-GilJesús Mingorance
Dec 3, 2010·Journal of Clinical Microbiology·Patrice NordmannTimothy R Walsh
Dec 7, 2010·International Journal of Antimicrobial Agents·Timothy R Walsh
Jan 5, 2011·Emerging Infectious Diseases·Olivier MoquetBenoit Garin
Feb 5, 2011·Emerging Infectious Diseases·Gisele PeiranoJohann D Pitout
Feb 24, 2011·Antimicrobial Agents and Chemotherapy·Gaelle CuzonPatrice Nordmann
Mar 15, 2011·Diagnostic Microbiology and Infectious Disease·Laurent PoirelPatrice Nordmann

❮ Previous
Next ❯

Citations

May 21, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Delphine GirlichThierry Naas
Sep 27, 2020·Antimicrobial Resistance and Infection Control·Mohammad SholehEbrahim Kouhsari
Jan 9, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Priya KannianChandran Priya
Oct 2, 2020·European Journal of Medicinal Chemistry·Lidia Moreira LimaEliezer J Barreiro
May 1, 2021·Nanomaterials·Foteini GkartziouSophia G Antimisiaris
Jul 22, 2021·International Journal of Nanomedicine·Di MeiYuanyuan Gao
Aug 5, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Raoudha DziriNaouel Klibi

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.