A review on bradykinin-related peptides isolated from amphibian skin secretion

Toxins
Xinping XiHang Fai Kwok

Abstract

Amphibian skin secretion has great potential for drug discovery and contributes hundreds of bioactive peptides including bradykinin-related peptides (BRPs). More than 50 BRPs have been reported in the last two decades arising from the skin secretion of amphibian species. They belong to the families Ascaphidae (1 species), Bombinatoridae (3 species), Hylidae (9 speices) and Ranidae (25 species). This paper presents the diversity of structural characteristics of BRPs with N-terminal, C-terminal extension and amino acid substitution. The further comparison of cDNA-encoded prepropeptides between the different species and families demonstrated that there are various forms of kininogen precursors to release BRPs and they constitute important evidence in amphibian evolution. The pharmacological activities of isolated BRPs exhibited unclear structure-function relationships, and therefore the scope for drug discovery and development is limited. However, their diversity shows new insights into biotechnological applications and, as a result, comprehensive and systematic studies of the physiological and pharmacological activities of BRPs from amphibian skin secretion are needed in the future.

References

Sep 1, 1979·Canadian Journal of Physiology and Pharmacology·J N DrouinD Regoli
Jun 1, 1975·General and Comparative Endocrinology·R S Dunn, A M Perks
Nov 1, 1992·Pharmacology & Therapeutics·J M Hall
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M RoseghiniM Simmaco
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·V ErspamerJ M Cei
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M RoseghiniC Severini
Jun 1, 1973·The American Journal of Physiology·T SekiE G Erdös
Feb 1, 1972·Comparative Biochemistry and Physiology. A, Comparative Physiology·S F RabitoR Segovia
Jan 1, 1971·Annual Review of Pharmacology·V Erspamer
Sep 1, 1966·British Journal of Pharmacology and Chemotherapy·A AnastasiV Erspamer
Apr 29, 1994·Journal of Medicinal Chemistry·D J KyleT M Stormann
Jan 1, 1997·General Pharmacology·J M Hall
Aug 1, 1997·Biological Reviews of the Cambridge Philosophical Society·B T Clarke
Feb 14, 1998·Journal of Natural Products·J W Daly
Apr 1, 1999·Regulatory Peptides·J M Conlon
Aug 13, 1999·The American Journal of Physiology·V VelardeA A Jaffa
Dec 30, 1999·Immunopharmacology·A DendorferP Dominiak
Mar 21, 2002·Clinical and Experimental Pharmacology & Physiology·D J Campbell
Sep 17, 2002·European Journal of Biochemistry·Tianbao ChenChris Shaw
Jun 1, 2005·General and Comparative Endocrinology·J Michael ConlonPeter W Abel
Sep 24, 2005·Journal of Pharmacological Sciences·Marie Eve MoreauAlbert Adam
Dec 7, 2005·Developmental and Comparative Immunology·Louise A Rollins-SmithJ Michael Conlon
Nov 23, 2006·Rapid Communications in Mass Spectrometry : RCM·Alan Hunter ThompsonStephen McClean
Nov 13, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Xiuhong LiuRen Lai
Dec 22, 2007·Genomics·Liwei ZhouQingwei Li

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Citations

Jul 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiang DuLei Wang
Feb 8, 2018·Canadian Journal of Physiology and Pharmacology·Xavier Charest-MorinFrançois Marceau
Nov 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alvaro SianoGeorgina G Tonarelli
Aug 11, 2016·Journal of Peptide Science : an Official Publication of the European Peptide Society·Hye-Jin GoNam Gyu Park
Nov 23, 2018·International Journal of Molecular Sciences·Jesús Hernández-PérezJorge Benavides
Dec 22, 2020·Mass Spectrometry Reviews·Albert T LebedevTatiana Y Samgina
Nov 7, 2019·Chembiochem : a European Journal of Chemical Biology·Anna Mary BenedettiAlan M Jones
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hassan MadkhaliZia Shariat-Madar

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Methods Mentioned

BETA
reverse-phase chromatography

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